A run-to-run control strategy for polymorphic transformation in pharmaceutical crystallization

被引：0
|
作者：
Hermanto, Martin Wijaya [1 ]
Braatz, Richard D. [2 ]
Chiu, Min-Sen [1 ]
机构：
[1] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117548, Singapore
[2] Univ Illinois, Dept Chem & Biomol Engn, Chicago, IL 60680 USA
来源：
PROCEEDINGS OF THE 2006 IEEE INTERNATIONAL CONFERENCE ON CONTROL APPLICATIONS, VOLS 1-4 | 2006年
关键词：
D O I：
暂无
中图分类号：
TP [自动化技术、计算机技术];
学科分类号：
0812 ;
摘要：
Polymorphism is a phenomenon that a substance can have more than one crystal form, each with distinct characteristics. Consequently, controlling polymorphism in drug manufacturing industries are crucial in order to ensure consistent production of the desired polymorph. In this paper, a run-to-run concentration control (C-control) based on iterative learning control is developed. As a case study, a model of polymorphic transformation of L-Glutamic acid from metastable alpha-form to stable beta-form, where the yield of beta-form is to be maximized, is used to illustrate the proposed run-to-run C-control and its advantage over the conventional C-control.
引用
收藏
页码：1300 / 1305
页数：6
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