Safety and immunogenicity of the 23-valent pneumococcal polysaccharide vaccine at 12 months of age, following one, two, or three doses of the 7-valent pneumococcal conjugate vaccine in infancy

被引：28

作者：

Russell, F. M. ^{[1
,7
]}

Licciardi, P. V. ^{[2
]}

Balloch, A. ^{[2
]}

Biaukula, V. ^{[3
]}

Tikoduadua, L. ^{[3
]}

Carapetis, J. R. ^{[4
]}

Nelson, J. ^{[4
]}

Jenney, A. W. J. ^{[1
]}

Waqatakirewa, L. ^{[3
]}

Colquhoun, S. ^{[1
]}

Cheung, Y. B. ^{[5
,6
]}

Tang, M. L. K. ^{[2
]}

Mulholland, E. K. ^{[4
,8
]}

机构：

[1] Univ Melbourne, Ctr Int Child Hlth, Dept Paediat, Royal Childrens Hosp, Melbourne, Vic, Australia

[2] Royal Childrens Hosp, Murdoch Childrens Res Inst, Melbourne, Vic, Australia

[3] Minist Hlth, Suva, Fiji

[4] Charles Darwin Univ, Menzies Sch Hlth Res, Darwin, NT 0909, Australia

[5] Singapore Clin Res Inst, Singapore, Singapore

[6] Duke NUS Grad Med Sch, Singapore, Singapore

[7] Univ Melbourne, Ctr Int Child Hlth, Dept Paediat, Melbourne, Vic, Australia

[8] London Sch Hyg & Trop Med, London WC1, England

来源：

VACCINE | 2010年 / 28卷 / 18期

基金：

英国医学研究理事会;

关键词：

Pneumococcal; Polysaccharide; Booster; ACUTE OTITIS-MEDIA; STREPTOCOCCUS-PNEUMONIAE; NASOPHARYNGEAL CARRIAGE; CHILDREN; ANTIBODY; EFFICACY; DISEASE; IMMUNIZATION; INFECTIONS; REDUCTION;

D O I：

10.1016/j.vaccine.2010.02.065

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Fijian infants aged 6 weeks were stratified by ethnicity and randomized to receive 0, 1, 2, or 3 PCV-7 doses with or without the 23-valent pneumococcal polysaccharide vaccine (PPV-23) at 12 months. Strong booster effects for all 7 PCV-7 serotypes were elicited, and for 4/7 serotypes these responses were highest in the single PCV-7 group. There were fourfold rises in GMC for all non-PCV-7 serotypes. By 17 months the PPV-23 group still had significantly higher GMC (each p < 0.001) for all serotypes. The PPV-23 was well tolerated and induced excellent responses for all serotypes which were greatest in the single PCV-7 group. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：3086 / 3094

页数：9

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