Pt(II) complexes with different N-donor aromatic ligands for specific inhibition of telomerase

被引：35

作者：

Cavigiolio, G

Benedetto, L

Boccaleri, E

Colangelo, D

Viano, I

Osella, D

机构：

[1] Univ Piemonte Orientale, Dipartimento Sci & Tecnol Avanzate, I-15100 Alessandria, Italy

[2] Univ Piemonte Orientale, Dipartimento Sci Med, I-15100 Alessandria, Italy

[3] Univ Turin, Dipartimento Chim, IFM, I-10125 Turin, Italy

来源：

INORGANICA CHIMICA ACTA | 2000年 / 305卷 / 01期

关键词：

antitumor agents; platinum complexes; isoquinoline complexes; telomerase;

D O I：

10.1016/S0020-1693(00)00114-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A number of cis-dichloroplatinum(II) derivatives containing aromatic N-donor ligands such as pyridine and/or 5-substituted isoquinolines have been synthesized and fully characterized, with particular use of Raman spectroscopy and mass spectrometry. These complexes have been tested for specific inhibition of telomerase, which could represent a selective target for cancer chemotherapy. The screening of such potential drugs has been performed by a biochemical assay on the isolated enzyme, It is noteworthy that the cis -[PtCl2(pyridine)(5-SO3H-isoquinoline)] compound exhibited remarkable telomerase inhibition at a concentration as low as 10(-7) M. (C) 2000 Elsevier Science S.A. All rights reserved.

引用

页码：61 / 68

页数：8

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