Ethyl 3-methyl-4-oxo-4,5-dihydro-1H-pyrrolo[2,3-d]pyridazine-2-carboxylate

被引:0
作者
Chen, Shi-Quan [2 ]
Jiang, Kai [3 ]
Wang, Shi-Fan [1 ,2 ]
机构
[1] Hainan Univ, Sch Ocean, Haikou 570228, Peoples R China
[2] Hainan Univ, Minist Educ, Key Lab Trop Biol Resources, Haikou 570228, Peoples R China
[3] Hainan Univ, Expt Teaching Ctr Marine Biol, Haikou 570228, Peoples R China
来源
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2010年 / 66卷
基金
中国国家自然科学基金;
关键词
DERIVATIVES;
D O I
10.1107/S1600536809055081
中图分类号
O7 [晶体学];
学科分类号
0702 ; 070205 ; 0703 ; 080501 ;
摘要
The title compound, C(10)H(11)N(3)O(3), was synthesized by the reaction of 3,5-bis(ethoxycarbonyl)-2-formyl-4-methyl-1H-pyrrole and hydrazine hydrate. The angle between the pyrrole ring and the pyridazinone ring is 0.93 (9)degrees. In the crystal, intermolecular N-H center dot center dot center dot O and N-H center dot center dot center dot N hydrogen-bond interactions link the molecules into a two-dimensional network.
引用
收藏
页码:O259 / U1522
页数:9
相关论文
共 8 条
[1]   TABLES OF BOND LENGTHS DETERMINED BY X-RAY AND NEUTRON-DIFFRACTION .1. BOND LENGTHS IN ORGANIC-COMPOUNDS [J].
ALLEN, FH ;
KENNARD, O ;
WATSON, DG ;
BRAMMER, L ;
ORPEN, AG ;
TAYLOR, R .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1987, (12) :S1-S19
[2]  
*BRUK AXS INC, 2002, SAINT SMART
[3]   Pyrrolopyridazine MEK inhibitors [J].
Chen, Z ;
Kim, SH ;
Barbosa, SA ;
Huynh, T ;
Tortolani, DR ;
Leavitt, KJ ;
Wei, DD ;
Marine, V ;
Ricca, CS ;
Gullo-Brown, J ;
Poss, MA ;
Vaccaro, W ;
Salvati, ME .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (03) :628-632
[4]   Synthesis and biological evaluation of 6-aryl-6H-pyrrolo[3,4-d]-pyridazine derivatives as high-affinity ligands of the α2δ subunit of voltage-gated calcium channels [J].
Hu, T ;
Stearns, BA ;
Campbell, BT ;
Arruda, JM ;
Chen, CX ;
Aiyar, J ;
Bezverkov, RE ;
Santini, A ;
Schaffhauser, H ;
Liu, WS ;
Venkatraman, S ;
Munoz, B .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (09) :2031-2034
[5]  
Sheldrick G.M., 1996, SADABS
[6]   A short history of SHELX [J].
Sheldrick, George M. .
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2008, 64 :112-122
[7]   Structure validation in chemical crystallography [J].
Spek, Anthony L. .
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2009, 65 :148-155
[8]   New pyrrolopyridazine derivatives as blue organic luminophors [J].
Swamy, KMK ;
Park, MS ;
Han, SJ ;
Kim, SK ;
Kim, JH ;
Lee, C ;
Bang, H ;
Kim, Y ;
Kim, SJ ;
Yoon, J .
TETRAHEDRON, 2005, 61 (43) :10227-10234