A Lipid-Soluble Red Ginseng Extract Inhibits the Growth of Human Lung Tumor Xenografts in Nude Mice

被引：34

作者：

Lee, Sung Dong ^{[2
]}

Park, Song-Kyu ^{[4
]}

Lee, Eun Sil ^{[5
,6
]}

Kim, Hwan Mook ^{[4
]}

Lee, Chang Woo ^{[4
]}

Lee, Kiho ^{[4
]}

Lee, Ki Hoon ^{[4
]}

Kang, Moo Rim ^{[4
]}

Lee, Kwang Seung ^{[5
]}

Lee, Junsoo ^{[6
]}

Hwang, Woo Ik ^{[3
]}

Kim, Dong Chung ^{[1
,7
]}

机构：

[1] Chungwoon Univ, Dept Human Nutr & Food Sci, Hongseong 350701, South Korea

[2] Korea Univ, Coll Hlth Sci, Dept Food & Nutr, Seoul, South Korea

[3] Korea Univ, Coll Med, Dept Biochem, Seoul, South Korea

[4] Korea Res Inst Biosci & Biotechnol, Bioevaluat Ctr, Ochang, South Korea

[5] NH Hansamin Co Ltd, Jeungpyeong, South Korea

[6] Chungbuk Natl Univ, Dept Food Sci & Technol, Cheongju, South Korea

[7] Sungkyunkwan Univ, Inst Basic Sci, Suwon, South Korea

来源：

JOURNAL OF MEDICINAL FOOD | 2010年 / 13卷 / 01期

关键词：

anticancer effect; human tumor xenograft; lipid-soluble ginseng extract; oral administration; CELL-PROLIFERATION; CANCER CELLS; INDUCTION; APOPTOSIS; SURVIVAL; RH-2; RATS;

D O I：

10.1089/jmf.2009.1142

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Lipid-soluble ginseng extract was prepared by n-hexane extraction of red ginseng. BALB/c-nu mice were inoculated with human lung cancer (NCI-H460) cells to establish a human tumor xenograft model in nude mice, and the lipid-soluble ginseng extract was orally administered. The tumor inhibitory rates of the lipid-soluble ginseng extract at doses of 0.1, 0.3, and 1.0 g/kg/day were 18.9% (P<.05), 60.0% (P<.001), and 67.5% (P<.001), respectively. The oral administration of the lipid-soluble extract of red ginseng showed a potent anticancer effect in nude mice bearing human lung cancer cells in a dose-dependent manner without any apparent toxicity. This lipid-soluble ginseng extract is a potential nontoxic anticancer supplement for the prevention and intervention of lung tumor growth through an oral administration route.

引用

页码：1 / 5

页数：5

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