High-frequency electroacupuncture evidently reinforces hippocampal synaptic transmission in Alzheimer's disease rats

被引：29

作者：

Li, Wei ^{[1
]}

Kong, Li-hong ^{[2
]}

Wang, Hui ^{[1
]}

Shen, Feng ^{[2
]}

Wang, Ya-wen ^{[2
]}

Zhou, Hua ^{[2
]}

Sun, Guo-jie ^{[2
]}

机构：

[1] Hubei Univ Chinese Med, Wuhan, Hubei Province, Peoples R China

[2] Hubei Univ Chinese Med, Sch Acupuncture Orthoped, Wuhan, Hubei Province, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2016年 / 11卷 / 05期

基金：

中国国家自然科学基金;

关键词：

nerve regeneration; Alzheimer's disease; frequency; electroacupuncture; long-term potentiation; long-term depression; learning and memory; Baihui (DU20); Shenshu (BL23); neural regeneration; PLASTICITY;

D O I：

10.4103/1673-5374.182708

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The frequency range of electroacupuncture in treatment of Alzheimer's disease in rats is commonly 2-5 Hz (low frequency) and 50-100 Hz (high frequency). We established a rat model of Alzheimer's disease by injecting beta-amyloid 1-42 (A beta(1-42)) into the bilateral hippocampal dentate gyrus to verify which frequency may be better suited in treatment. Electroacupuncture at 2 Hz or 50 Hz was used to stimulate Baihui (DU20) and Shenshu (BL23) acupoints. The water maze test and electrophysiological studies demonstrated that spatial memory ability was apparently improved, and the ranges of long-term potentiation and long-term depression were increased in Alzheimer's disease rats after electroacupuncture treatment. Moreover, the effects of electroacupuncture at 50 Hz were better than that at 2 Hz. These findings suggest that high-frequency electroacupuncture may enhance hippocampal synaptic transmission and potentially improve memory disorders in Alzheimer's disease rats.

引用

页码：801 / 806

页数：6

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