Pharmacogenetics in psychosis

被引：5
作者：
Collier, DA [1 ]
机构：
[1] Inst Psychiat, Mol Genet Sect, Div Psychol Med, London SE5 8AF, England
来源：
DRUG NEWS & PERSPECTIVES | 2003年 / 16卷 / 03期
关键词：
D O I：
10.1358/dnp.2003.16.3.737958
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Pharmacogenetics uses genetic information to tailor drug treatment to the individual, maximizing clinical response and minimizing side effects. Failure to respond to medication and adverse side effects are common problems in psychiatry. Intolerable side effects can lead to discontinuation of medication. Individual genetic differences can determine both clinical responses to medications and the adverse side effects experienced. To fully predict clinical response to psychotropic drug treatment we must consider social, demographic and clinical factors such as compliance, social support and history of birth trauma, in addition to genetic influence on susceptibility and etiology. (C) 2003 Prous Science. All rights reserved.
引用
收藏
页码：159 / 165
页数：7
相关论文
共 47 条
[1]   Clozapine pharmacokinetics and pharmacodynamics studied with CYP1A2-null mice [J].
Aitchison, KJ ;
Jann, MW ;
Zhao, JH ;
Sakai, T ;
Zaher, H ;
Wolff, K ;
Collier, DA ;
Kerwin, RW ;
Gonzalez, FJ .
JOURNAL OF PSYCHOPHARMACOLOGY, 2000, 14 (04) :353-359
[2]   ASSOCIATION BETWEEN CLOZAPINE RESPONSE AND ALLELIC VARIATION IN 5HT(2A) RECEPTOR GENE [J].
ARRANZ, M ;
COLLIER, D ;
SODHI, M ;
BALL, D ;
ROBERTS, G ;
PRICE, J ;
SHAM, P ;
KERWIN, R .
LANCET, 1995, 346 (8970) :281-282
[3]   Pharmacogenetic prediction of clozapine response [J].
Arranz, MJ ;
Munro, J ;
Birkett, J ;
Bolonna, A ;
Mancama, D ;
Sodhi, M ;
Lesch, KP ;
Meyer, JFW ;
Sham, P ;
Collier, DA ;
Murray, RM ;
Kerwin, RW .
LANCET, 2000, 355 (9215) :1615-1616
[4]   Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine [J].
Arranz, MJ ;
Munro, J ;
Owen, MJ ;
Spurlock, G ;
Sham, PC ;
Zhao, J ;
Kirov, G ;
Collier, DA ;
Kerwin, RW .
MOLECULAR PSYCHIATRY, 1998, 3 (01) :61-66
[5]   Meta-analysis of studies on genetic variation in 5-HT2A receptors and clozapine response [J].
Arranz, MJ ;
Munro, J ;
Sham, P ;
Kirov, G ;
Murray, RM ;
Collier, DA ;
Kerwin, RS .
SCHIZOPHRENIA RESEARCH, 1998, 32 (02) :93-99
[6]  
Avram AM, 2001, ANN PHARMACOTHER, V35, P1381
[7]  
BARNES TRE, 1993, ASSESSMENT PSYCHOSES
[8]   Association of the MscI polymorphism of the dopamine D3 receptor gene with tardive dyskinesia in schizophrenia [J].
Basile, VS ;
Masellis, M ;
Badri, F ;
Paterson, AD ;
Meltzer, HY ;
Lieberman, JA ;
Potkin, SG ;
Macciardi, F ;
Kennedy, JL .
NEUROPSYCHOPHARMACOLOGY, 1999, 21 (01) :17-27
[9]   Lack of association between serotonin-2A receptor gene (HTR2A) polymorphisms and tardive dyskinesia in schizophrenia [J].
Basile, VS ;
Ozdemir, V ;
Masellis, M ;
Meltzer, HY ;
Lieberman, JA ;
Potkin, SG ;
Macciardi, FM ;
Petronis, A ;
Kennedy, JL .
MOLECULAR PSYCHIATRY, 2001, 6 (02) :230-234
[10]   CLOZAPINE DISPOSITION COVARIES WITH CYP1A2 ACTIVITY DETERMINED BY A CAFFEINE TEST [J].
BERTILSSON, L ;
CARRILLO, JA ;
DAHL, ML ;
LLERENA, A ;
ALM, C ;
BONDESSON, U ;
LINDSTROM, L ;
DELARUBIA, IR ;
RAMOS, S ;
BENITEZ, J .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1994, 38 (05) :471-473
12345