Efficacy of Active Carbon towards the Absorption of Deoxynivalenol in Pigs

被引：28
作者：
Devreese, Mathias [1 ]
Antonissen, Gunther [1 ,2 ]
De Backer, Patrick [1 ]
Croubels, Siska [1 ]
机构：
[1] Univ Ghent, Dept Pharmacol Toxicol & Biochem, Fac Vet Med, B-9820 Merelbeke, Belgium
[2] Univ Ghent, Dept Pathol Bacteriol & Avian Dis, Fac Vet Med, B-9820 Merelbeke, Belgium
来源：
TOXINS | 2014年 / 6卷 / 10期
关键词：
deoxynivalenol; absorption model; pig; mycotoxin binder; efficacy testing; FUSARIUM TOXIN DEOXYNIVALENOL; MYCOTOXINS; FEED; DON; METABOLISM; REDUCTION;
D O I：
10.3390/toxins6102998
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
In order to assess the in vivo efficacy of mycotoxin binders, specific toxicokinetic parameters should be measured according to European guidelines. For this purpose, an absorption model in pigs is described with emphasis on absorption kinetics. Pigs received a single oral bolus of the mycotoxin deoxynivalenol alone or in combination with active carbon (applied as mycotoxin binder). After administration of deoxynivalenol alone, significant plasma amounts of deoxynivalenol were detected and kinetic parameters were calculated using a one compartmental model. Activated carbon completely prevented the absorption of deoxynivalenol as no plasma amounts could be detected.
引用
收藏
页码：2998 / 3004
页数：7
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