Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp MK929-43F1 -: Taxonomy, fermentation, isolation and biological activities

被引：117

作者：

Nakae, K

Yoshimoto, Y

Sawa, T

Homma, Y

Hamada, M

Takeuchi, T

Imoto, M

机构：

[1] Keio Univ, Fac Sci & Technol, Dept Appl Chem, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan

[2] Inst Microbial Chem, Shinagawa Ku, Tokyo 1410021, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2000年 / 53卷 / 10期

关键词：

D O I：

10.7164/antibiotics.53.1130

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new compound, migrastatin, was isolated from a cultured broth of Streptomyces sp. MK929-43F1, as an inhibitor of tumor cell migration. It was purified by column chromatographies on silica gel and Sephadex LH-20 and HPLC. Migrastatin has the molecular formula of C27H39NO7 consisting of 14-membered macrolide and glutarimide moiety. It inhibited spontaneous migration of human esophageal cancer EC17 cells. Migration inhibitory activity of migrastatin was not dependent on cytotoxicity or inhibition of protein synthesis.

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页码：1130 / 1136

页数：7

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