COVID-19: Loss of bridging between innate and adaptive immunity?

被引：16

作者：

Rao, Vishal U. S. ^{[1
]}

Arakeri, Gururaj ^{[1
]}

Subash, Anand ^{[1
]}

Rao, Jyothsna ^{[2
]}

Jadhav, Sachin ^{[3
]}

Sayeed, Mufti Suhail ^{[4
]}

Rao, Gururaj ^{[2
]}

Brennan, Peter A. ^{[5
]}

机构：

[1] HCG Canc Hosp, Dept Head & Neck Oncol, Bengaluru, Karnataka, India

[2] HealthCare Global Enterprises Ltd, Int Stemcell Serv Ltd, iCREST, Bengaluru, Karnataka, India

[3] HCG Canc Hosp, Dept Hematol Immunol & Med Oncol, Bengaluru, Karnataka, India

[4] HCG Canc Hosp, Dept Translat Med & Therapeut, Bengaluru, Karnataka, India

[5] Queen Alexandra Hosp, Dept Oral & Maxillofacial Surg, Portsmouth, Hants, England

来源：

MEDICAL HYPOTHESES | 2020年 / 144卷

关键词：

COVID-19; SARS-CoV2; Adaptive immunity; Innate immunity; Cytokines; Interferons (IFNs); CELLS;

D O I：

10.1016/j.mehy.2020.109861

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

COVID-19 has spread to most countries in the world. However, there are some striking differences in how COVID-19 is behaving in different age groups. While data on COVID-19 is limited, children appear to be less susceptible to severe disease. These unique characteristics may be considered as a potential link to understanding the immune system and response in COVID-19 and lead to an effective cure to the disease. We suggest a possible role of loss of bridging between innate and adaptive immunity in COVID-19 and a potential treatment modality also discussed.

引用

页数：2

共 13 条

[1] Altered innate immune functioning of dendritic cells in elderly humans: A role of phosphoinositide 3-kinase-signaling pathway [J].

Agrawal, Anshu ;

Agrawal, Sudhanshu ;

Cao, Jia-Ning ;

Su, Houfen ;

Osann, Kathryn ;

Gupta, Sudhir .

JOURNAL OF IMMUNOLOGY, 2007, 178 (11) :6912-6922

[2]

[Anonymous], NTR REFERENCE

[3] Influenza-Induced Production of Interferon-Alpha is Defective in Geriatric Individuals [J].

Canaday, David H. ;

Amponsah, Naa Ayele ;

Jones, Leola ;

Tisch, Daniel J. ;

Hornick, Thomas R. ;

Ramachandra, Lakshmi .

JOURNAL OF CLINICAL IMMUNOLOGY, 2010, 30 (03) :373-383

[4] We urgently need guidelines for managing COVID-19 in children with comorbidities [J].

Dayal, Devi .

ACTA PAEDIATRICA, 2020, 109 (07) :1497-1498

[5] Mathematical modeling of interaction between innate and adaptive immune responses in COVID-19 and implications for viral pathogenesis [J].

Du Sean Quan ;

Yuan Weiming .

JOURNAL OF MEDICAL VIROLOGY, 2020, 92 (09) :1615-1628

[6]

Hedrich MC, 2020, CLIN IMMUNOL, V10, DOI [10.1016/j.clim.2020.10842, DOI 10.1016/J.CLIM.2020.10842]

[7] Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China [J].

Huang, Chaolin ;

Wang, Yeming ;

Li, Xingwang ;

Ren, Lili ;

Zhao, Jianping ;

Hu, Yi ;

Zhang, Li ;

Fan, Guohui ;

Xu, Jiuyang ;

Gu, Xiaoying ;

Cheng, Zhenshun ;

Yu, Ting ;

Xia, Jiaan ;

Wei, Yuan ;

Wu, Wenjuan ;

Xie, Xuelei ;

Yin, Wen ;

Li, Hui ;

Liu, Min ;

Xiao, Yan ;

Gao, Hong ;

Guo, Li ;

Xie, Jungang ;

Wang, Guangfa ;

Jiang, Rongmeng ;

Gao, Zhancheng ;

Jin, Qi ;

Wang, Jianwei ;

Cao, Bin .

LANCET, 2020, 395 (10223) :497-506

[8] Principles of Effective and Robust Innate Immune Response to Viral Infections: A Multiplex Network Analysis [J].

Huang, Yufan ;

Dai, Huaiyu ;

Ke, Ruian .

FRONTIERS IN IMMUNOLOGY, 2019, 10 :1736

[9] Interferon priming enables cells to partially overturn the SARS coronavirus-induced block in innate immune activation [J].

Kuri, Thomas ;

Zhang, Xiaonan ;

Habjan, Matthias ;

Martinez-Sobrido, Luis ;

Garcia-Sastre, Adolfo ;

Yuan, Zhenghong ;

Weber, Friedemann .

JOURNAL OF GENERAL VIROLOGY, 2009, 90 :2686-2694

[10] Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults [J].

Ludvigsson, Jonas F. .

ACTA PAEDIATRICA, 2020, 109 (06) :1088-1095

← 1 2 →