Syntheses, Structures, and Antimicrobial Activity of New Remarkably Light-Stable and Water-Soluble Tris(pyrazolyl)methanesulfonate Silver(I) Derivatives of N-Methyl-1,3,5-triaza-7-phosphaadamantane Salt - [mPTA]BF4

被引：46

作者：

Smolenski, Piotr ^{[1
]}

Pettinari, Claudio ^{[2
]}

Marchetti, Fabio ^{[4
]}

Guedes da Silva, M. Fatima C. ^{[5
]}

Lupidi, Giulio ^{[2
]}

Patzmay, Gretta Veronica Badillo ^{[3
]}

Petrelli, Dezemona ^{[3
]}

Vitali, Luca A. ^{[2
]}

Pombeiro, Armando J. L. ^{[5
]}

机构：

[1] Univ Wroclaw, Fac Chem, PL-50383 Wroclaw, Poland

[2] Univ Camerino, Chem Sect, Sch Pharm, I-62032 Camerino, MC, Italy

[3] Univ Camerino, Sch Biosci & Biotechnol, I-62032 Camerino, MC, Italy

[4] Univ Camerino, Sch Sci & Technol, Chem Sect, I-62032 Camerino, MC, Italy

[5] Univ Lisbon, Inst Super Tecn, Ctr Quim Estrutural, P-1049001 Lisbon, Portugal

来源：

INORGANIC CHEMISTRY | 2015年 / 54卷 / 02期

关键词：

1,3,5-TRIAZA-7-PHOSPHAADAMANTANE PTA; IN-VITRO; COMPLEXES; LIGANDS; METAL; COPPER(I); BINDING; DNA; TRIS(PYRAZOLYL)BORATE; GOLD(I);

D O I：

10.1021/ic501855k

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Two new silver(I) complexes of formula [Ag(mPTA)(4)](Tpms)4(BF4) (1) and [Ag(Tpms)(mPTA)](BF4) (2) (mPTA = N-methyl-1,3,5-triaza-7-phosphaadamantane cation, Tpms = tris(pyrazol-1-yl)methanesulfonate anion) have been synthesized and fully characterized by elemental analyses, H-1 and P-31{H-1} NMR, ESI-MS, and IR spectroscopic techniques. The single-crystal X-ray diffraction study of 1 discloses a noncoordinated nature of the Tpms species, existing as counterions around the highly charged metal center [Ag(mPTA)](5+), 1 being the first reported coordination compound bearing a kappa(0)-Tpms. 1 features high solubility and stability in water (S25 degrees C approximate to 30 mg.mL(-1)). The two complexes interact with calf thymus DNA via intercalation mode, binding to the BSA with decrease of its tryptophan fluorescence with a static quenching mechanism. The two new silver complexes exhibit significant antibacterial and antifungal activities screened in vitro against the standard strains of Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans.

引用

页码：434 / 440

页数：7

共 64 条

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