Alveolar soft part sarcoma presenting in an unusual laryngeal location

被引:0
作者
Jang, Sylvia [1 ]
Emanuel, Anthony [1 ]
Worley, Mitchell [2 ]
Richardson, Mary [1 ]
机构
[1] Med Univ South Carolina, Dept Pathol & Lab Med, Charleston, SC 29425 USA
[2] Med Univ South Carolina, Dept Otolaryngol Head & Neck Surg, Charleston, SC 29425 USA
关键词
ear; nose and throat; otolaryngology; head and neck cancer; pathology; head and neck surgery; ENT; BETA-INDUCED TRANSCRIPTION; TFE3; GENE; ACTIVATOR; MICROPHTHALMIA; EXPRESSION;
D O I
10.1136/bcr-2020-236867
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Alveolar soft part sarcoma (ASPS) is a rare malignant neoplasm that tends to occur in the deep soft tissues of both adults and children. ASPS has a progressive clinical course that is unfortunately characterised by late metastases and an overall poor prognosis. Although the tumour has been reported in a wide range of anatomic sites, few cases of primary laryngeal ASPS are reported in the literature. Here, we report the case of a 24-year-old man with no significant medical history who presented with progressive mild dysphonia and hoarseness. Imaging studies revealed a well-circumscribed, partially cystic submucosal mass with involvement of the right vocal fold and other local structures, and the patient was referred for surgical excision. Morphological and immunohistochemical examination of the excised lesion revealed ASPS. The findings of this case are compared with those of seven additional cases of primary laryngeal ASPS, which were found following literature review.
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页数:6
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