Overwhelming Disseminated Herpes Simplex Virus Type 2 Infection in a Patient With Severe Burn Injury: Case Report and Literature Review

被引：9
作者：
Peppercorn, Amanda [1 ]
Veit, Lindsay [2 ]
Sigel, Carlie [3 ]
Weber, David J. [4 ]
Jones, Samuel [5 ]
Cairns, Bruce A. [5 ]
机构：
[1] Univ N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Sch Med, Chapel Hill, NC 27599 USA
[3] Mem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, New York, NY 10021 USA
[4] UNC Hlth Care, Dept Hosp Epidemiol, Chapel Hill, NC USA
[5] Univ N Carolina, Dept Surg, Chapel Hill, NC 27599 USA
来源：
JOURNAL OF BURN CARE & RESEARCH | 2010年 / 31卷 / 03期
关键词：
ACYCLOVIR-RESISTANT; THERMAL-INJURY; VARICELLIFORM ERUPTION; IMMUNE-RESPONSE; UNITED-STATES; HEPATITIS; FOSCARNET; FULMINANT; CELLS; MICE;
D O I：
10.1097/BCR.0b013e3181db51cb
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Viral-mediated organ disease is an infrequent but recognized complication of severe burn injury. This occurs primarily because of herpes family viruses such as cytomegalovirus, herpes simplex virus (HSV), and Epstein-Barr virus given their ability to establish lifelong latency after primary infection and reactivate in the setting of altered immune function. In this report, we describe a severely burned patient who succumbed to fulminant HSV-2 pneumonitis and hepatitis, and summarize the existing literature on HSV infections in this unique patient population. To our knowledge, this is the first report of disseminated visceral HSV-2 infection in a burn patient in the medical literature. (J Burn Care Res 2010; 31: 492-498)
引用
收藏
页码：492 / 498
页数：7
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