Copper-Catalyzed Chlorination of Functionalized Arylboronic Acids

被引：80

作者：

Wu, Hong ^{[1
]}

Hynes, John, Jr. ^{[1
]}

机构：

[1] Bristol Myers Squibb Co, Discovery Chem, Princeton, NJ 08543 USA

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 06期

关键词：

BORONIC ACIDS; ARYL CHLORIDES; VINYLIC ORGANOBORANES; STEREOSPECIFIC SYNTHESIS; CESIUM FLUOROXYSULFATE; REDUCTIVE ELIMINATION; COUPLING REACTIONS; FACILE SYNTHESIS; IODIDES; MILD;

D O I：

10.1021/ol9029337

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild, efficient, Cu(l)-catalyzed method for the conversion of arylboronic acids to aryl chlorides is reported. This method is particularly useful for the conversion of electron-deficient arylboronic acids to aryl chlorides, a transformation that is inefficient in the absence of Cu catalysis.

引用

页码：1192 / 1195

页数：4

共 34 条

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