Synthesis and biological evaluation of 1,2,4-oxadiazole linked imidazopyrazine derivatives as anticancer agents

被引：0

作者：

Reddy, Kotthireddy Thirumal ^{[1
]}

Sreenivasulu, Reddymasu ^{[2
]}

Raju, Rudraraju Ramesh ^{[1
]}

机构：

[1] Acharya Nagarjuna Univ, Dept Chem, Nagarjuna Nagar 522510, Andhra Pradesh, India

[2] Jawaharlal Nehru Technol Univ, Univ Coll Engn Autonomous, Dept Chem, Kakinada 533003, Andhra Pradesh, India

来源：

JOURNAL OF THE INDIAN CHEMICAL SOCIETY | 2019年 / 96卷 / 08期

关键词：

Imidazo[1,2-a]pyrazine; phidianidines A; phidianidines B; cytotoxicity; MOLECULAR DOCKING; ELLIPTICINE DERIVATIVES; AMIDE DERIVATIVES; INHIBITORS; DESIGN; PHIDIANIDINES; ANALOGS;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of new 1,2,4-oxadiazole linked imidazopyrazines (10a-j) were synthesized and evaluated for their cytotoxic activity against various human cancer cell lines, such as MCF-7 (breast), A-549 (lung), and A375 (melanoma). These compounds showed moderate to appreciable anticancer activities. Among them, compounds 10b (MCF-7 = 0.68 +/- 0.03 mu M, A-549 = 1.56 +/- 0.061 mu M and A-375 = 0.79 +/- 0.033 mu M), 10c (MCF-7 = 2.11 +/- 0.14 mu M, A-549 = 1.02 +/- 0.043 mu M and A-375 = 0.34 +/- 0.016 mu M), 10d (MCF-7 = 1.45 +/- 0.06 mu M, A-549 = 0.90 +/- 0.032 mu M and A-375 = 2.18 +/- 0.112 mu M), 10f (MCF-7 = 1.35 +/- 0.058 mu M, A549 = 0.55 +/- 0.001 11M and A-375 = 1.67 +/- 0.06 M) and 10i (MCF-7 = 0.22 +/- 0.009 AM, A-549 = 1.09 +/- 0.041 i..tM and A-375 = 1.18 +/- 0.054 mu M) were showed more potent activity than adriamycin (MCF-7 = 2.02 +/- 0.078 mu M, A-549 = 2.18 +/- 0.081 mu M and A-375 = 5.51 +/- 0.203 mu M).

引用

页码：1085 / 1090

页数：6

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