Synthesis and antimicrobial activities of some novel 4-substituted pyrazoline derivatives

A series of 5-aryl-3-isopropy1-4-[N-phenyl-aminocarbonyl]-4,5-dihydro-1H-pyrazoles were synthesized by the reaction between 3-aryl-2-isobutanoyl-N-phenyl-acrylamide with hydrazine hydrate in acetic acid as solvent gives acetyl pyrazoline. All the compounds have been evaluated for their in vitro biological assay like antibacterial activity towards Gram-positive and Gram-negative bacterial strains and antifungal activity towards Aspergillus niger at a concentration of 40 mu g. The biological activities of synthesized compounds were compared with standard drugs.