Morphology of experimentally induced tumors of the sympathetic nervous system in rats

被引：1

作者：

Beniashvili, DS ^{[1
]}

Anisimov, VN

机构：

[1] E Wolfson Med Ctr, Dept Pathol, Holon, Israel

[2] NN Petrov Oncol Res Inst, Dept Carcinogenesis & Oncogerontol, St Petersburg, Russia

来源：

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY | 2004年 / 56卷 / 1-2期

关键词：

induced tumors of sympathetic nervous system; morphology of ganglioneuromas; ganglioneuroblastomas and neuroblastomas; rat; nitrosoethylurea; continous light;

D O I：

10.1016/j.etp.2004.05.002

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Seventeen tumors of the sympathetic nervous system were discovered in offspring of rats exposed in utero at a single dose of 80 mg/kg of N-nitrosoethylurea at the day 16-19 of pregnancy, and then to constant light regimen. These tumors were classified as follows: benign - ganglioneuroma (six cases) and malignant - ganglioneuroblastoma (four cases) and neuroblastoma (seven cases). The most frequent location was in the sympathetic trunk in the mediastinum and in the retroperitoneal space. Morphological features of these induced tumors represent a model for similar neoplasms in humans in childrens' age. (C) 2004 Elsevier GmbH. All rights reserved.

引用

页码：53 / 58

页数：6

共 32 条

[1]

Beniashvili D. Sh, 1992, Voprosy Onkologii (St. Petersburg), V38, P864

[2] MORPHOLOGY OF EXPERIMENTAL-TUMORS OF THE SYMPATHETIC NERVOUS-SYSTEM [J].