Low-grade inflammation, CoVID-19, and obesity: clinical aspect and molecular insights in childhood and adulthood

被引：22

作者：

Muscogiuri, Giovanna ^{[1
,2
,3
]}

Bettini, Silvia ^{[4
]}

Boschetti, Mara ^{[5
,6
,7
]}

Barrea, Luigi ^{[8
]}

Savastano, Silvia ^{[1
,3
]}

Colao, Annamaria ^{[1
,2
,3
]}

机构：

[1] Federico II Univ Naples, Sch Med, Dipartimento Med Clin & Chirurg, Unita Endocrinol, Via Sergio Pansini 5, I-80131 Naples, Italy

[2] Univ Naples Federico II, Cattedra Unesco Educ Salute & Allo Sviluppo, Naples, Italy

[3] Univ Med Sch Naples, Endocrinol Unit, Dept Clin Med & Surg, Ctr Italiano Cura & Benessere Paziente Con Ob, Naples, Italy

[4] Univ Padua, Dept Med, Padua, Italy

[5] IRCCS Osped Policlin San Martino, Endocrinol Unit, Genoa, Italy

[6] Univ Genoa, Endocrinol Unit, Dept Internal Med & Med Specialties DIMI, Genoa, Italy

[7] Univ Genoa, Ctr Excellence Biomed Res CEBR, Genoa, Italy

[8] Univ Telemat Pegaso, Dipartimento Sci Umanistiche, I-80143 Naples, Italy

来源：

INTERNATIONAL JOURNAL OF OBESITY | 2022年 / 46卷 / 07期

关键词：

ADIPOSE-TISSUE; INSULIN-RESISTANCE; LINKING OBESITY; DISEASE; CORONAVIRUS; SARS-COV-2; NUTRITION; SYSTEM; ACE2;

D O I：

10.1038/s41366-022-01111-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The new 2019 coronavirus 19 disease (CoVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a serious threat to health systems. As a global health problem, this pandemic poses a huge threat to people and is responsible for significant morbidity and mortality worldwide. On the other hand, obesity has also reached epidemic proportions and poses another challenge to the healthcare system. There is increasing evidence of a strong association between obesity and CoVID-19 disease, but the mechanisms underlying the link between the two remain unclear and the role of obesity also remains to be elucidated. In particular obesity-related low-grade inflammation has been hypothesized as the Achille's heel that could predispose subjects with obesity to a more severe CoVID-19 compared to subjects with normal weight. Hence, we summarized recent evidence on the role of low-grade inflammation in clinical aspects of CoVID-19 in subjects with obesity in both childhood and adulthood. Further, we provide molecular insights to explain this link.

引用

页码：1254 / 1261

页数：8

共 120 条

[1] The renin-angiotensin-aldosterone system as a link between obesity and coronavirus disease 2019 severity [J].