Immunohistochemical distribution of neurotrophins and their receptors in the rat retina and the effects of ischemia and reperfusion

被引：75

作者：

Vecino, E ^{[1
]}

Caminos, E

Ugarte, M

Martín-Zanca, D

Osborne, NN

机构：

[1] Univ Basque Country, Fac Med, Dept Biol Celular & Ciencias Morfolog, Vizcaya, Spain

[2] Univ Salamanca, Fac Med, Dept Biol Celular & Patol, E-37008 Salamanca, Spain

[3] Univ Salamanca, CSIC, Dept Genet Microbiol, E-37008 Salamanca, Spain

[4] Univ Oxford, Nuffield Lab Ophthalmol, Oxford OX2 6AW, England

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1998年 / 30卷 / 03期

关键词：

neurotrophins; ischemia; retina; TrK; BDNF; NGF; NT3; NT4; p75;

D O I：

10.1016/S0306-3623(97)00361-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Neurotrophins are molecules that regulate the survival, development and maintenance of specific functions in different populations of nerve cells. 2. In the present work, we studied the localization, at the cellular level, of the different neurotrophins and their receptors within the rat retina in control and after ischemia-reperfusion of the retina; We found variations in the localization of some of these molecules depending on the reperfusion time of the retina after the ischemic lesion, 3. Thus it is suggested that the changes in the distribution and concentration of neurotrophins and their receptors caused by ischemia are protective reactions related to neuronal damage and synaptic reorganization. (C) 1998 Elsevier Science Inc.

引用

页码：305 / 314

页数：10

共 92 条

[1] RECOVERY FROM EDEMA AND OF PROTEIN-SYNTHESIS DIFFERS BETWEEN THE CORTEX AND CAUDATE FOLLOWING TRANSIENT FOCAL CEREBRAL-ISCHEMIA IN RATS [J].