Enantiospecific total synthesis of a novel arachidonic acid metabolite 3-hydroxyeicosatetraenoic acid

被引：33

作者：

Bhatt, RK

Falck, JR

Nigam, S ^{[1
]}

机构：

[1] Univ Med Ctr Benjamin Franklin, Dept Gynecol, Eicosanoid Res Div, D-12200 Berlin, Germany

[2] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75235 USA

[3] Univ Texas, SW Med Ctr, Dept Pharmacol, Dallas, TX 75235 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 3-4期

关键词：

D O I：

10.1016/S0040-4039(97)10565-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantiomers R- and S-3-hydroxyeicosatetraenoic acid 11a, 11b were synthesized from coupling of a chiral aldehyde 7 with a Wittig salt 4, which were derived from 2-deoxy-D-ribose and arachidonic acid, respectively. (C) 1997 Elsevier Science Ltd. All rights reserved.

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页码：249 / 252

页数：4

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