Neuromuscular mechanisms of primary peristalsis

被引:20
作者
Diamant, NE [1 ]
机构
[1] Univ Toronto, Toronto Hosp, Western Div, Dept Physiol & Med, Toronto, ON M5T 258, Canada
关键词
D O I
10.1016/S0002-9343(97)00320-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Primary peristalsis of the esophagus is initiated by the act of swallowing, Control of the orderly contraction must take into account coordination of the activity in the esophageal body with the sphincters at either end, integration of activity between the striated and smooth muscle portions of the esophagus, and the central and peripheral neural and muscular control mechanisms present. Peristalsis in the striated section is directed by sequential vagal excitation arising in a brainstem "Central Program Generator." Peristalsis in the smooth muscle section involves the interaction of central and peripheral neural mechanisms and probably the interaction between these neural mechanisms and smooth muscle properties. Coordination of activity between the striated and smooth muscle portions has similar multifaceted neural and mechanical components. In the smooth muscle, 2 main neural mechanisms, a cholinergic excitatory one and a nonadrenergic, noncholinergic (NANC) inhibitory one interact together and with central and local influences to regulate the amplitude, velocity, and direction of propagation of the peristaltic contraction. (C) 1997 by Excerpta Medica, Inc.
引用
收藏
页码:40S / 43S
页数:4
相关论文
共 53 条
[1]  
AMRI M, 1984, EXP BRAIN RES, V55, P105
[2]  
AMRI M, 1982, EXP BRAIN RES, V48, P355
[3]   ROLE OF NITRIC-OXIDE IN ESOPHAGEAL PERISTALSIS [J].
ANAND, N ;
PATERSON, WG .
AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 266 (01) :G123-G131
[4]   EFFECTS OF HINDBRAIN STIMULATION ON LOWER ESOPHAGEAL SPHINCTER PRESSURE IN THE CAT [J].
BARONE, FC ;
LOMBARDI, DM ;
ORMSBEE, HS .
AMERICAN JOURNAL OF PHYSIOLOGY, 1984, 247 (01) :G70-G78
[5]   BRAIN-STEM LOCALIZATION OF RODENT ESOPHAGEAL PREMOTOR NEURONS REVEALED BY TRANSNEURONAL PASSAGE OF PSEUDORABIES VIRUS [J].
BARRETT, RT ;
BAO, XM ;
MISELIS, RR ;
ALTSCHULER, SM .
GASTROENTEROLOGY, 1994, 107 (03) :728-737
[6]   MYOGENIC PERISTALSIS IN ISOLATED PREPARATIONS OF CHICKEN ESOPHAGUS [J].
BARTLET, AL .
BRITISH JOURNAL OF PHARMACOLOGY, 1973, 48 (01) :36-47
[7]  
BENNETT JA, 1985, J PHYSIOL-LONDON, V369, P1
[8]  
BERMAN AL, 1968, BRAIN STEM CAT CYTOA
[10]  
BIEGER D, 1991, Dysphagia, V6, P147, DOI 10.1007/BF02493518