Immunohistochemistry in the Diagnosis of Hepatocellular Carcinoma

被引：26

作者：

Choi, Won-Tak ^{[1
]}

Kakar, Sanjay ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Pathol, 505 Parnassus Ave,M552,Box 0102, San Francisco, CA 94143 USA

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2017年 / 46卷 / 02期

关键词：

Hepatocellular carcinoma; Hepatocellular adenoma; Focal nodular hyperplasia; Well-differentiated hepatocellular lesion; Immunohistochemistry; FOCAL NODULAR HYPERPLASIA; MALIGNANT POTENTIAL PROPOSAL; GLYPICAN-3; EXPRESSION; RENAL-CELL; DIFFERENTIAL-DIAGNOSIS; METASTATIC CARCINOMAS; GLUTAMINE-SYNTHETASE; MONOCLONAL-ANTIBODY; DYSPLASTIC NODULES; HEP PAR-1;

D O I：

10.1016/j.gtc.2017.01.006

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Hepatocellular carcinoma (HCC) can be difficult to distinguish from its mimics, including metastatic tumor, benign hepatocellular lesion, and high-grade dysplastic nodule, especially when limited biopsy material is available. Hence, the judicious use of immunohistochemical stains is necessary to establish a correct diagnosis. This article describes advantages and disadvantages of immunohistochemical markers that are most commonly used to distinguish between these lesions. Diagnostic workup of malignant liver mass (HCC and its histologic variants vs metastatic tumor) as well as well-differentiated hepatocellular lesion (well-differentiated HCC vs focal nodular hyperplasia vs hepatocellular adenoma) is also discussed.

引用

页码：311 / +

页数：16

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