Genetic Insights into Feline Parvovirus: Evaluation of Viral Evolutionary Patterns and Association between Phylogeny and Clinical Variables

被引:20
作者
Tucciarone, Claudia Maria [1 ]
Franzo, Giovanni [1 ]
Legnardi, Matteo [1 ]
Lazzaro, Elena [1 ]
Zoia, Andrea [2 ]
Petini, Matteo [2 ]
Furlanello, Tommaso [3 ]
Caldin, Marco [2 ]
Cecchinato, Mattia [1 ]
Drigo, Michele [1 ]
机构
[1] Univ Padua, Dept Anim Med Prod & Hlth MAPS, Viale Univ 16, I-35020 Legnaro, Italy
[2] San Marco Vet Clin, Div Internal Med, Viale Ind 3, I-35030 Veggiano, Italy
[3] San Marco Vet Private Clin, Vet Diagnost Lab, Viale Ind 3, I-35030 Veggiano, Italy
来源
VIRUSES-BASEL | 2021年 / 13卷 / 06期
关键词
feline panleukopenia; molecular epidemiology; phylodynamics; disease severity; canine parvovirus; CANINE PARVOVIRUS; PANLEUKOPENIA VIRUS; CATS; EMERGENCE; ACCURACY; HISTORY;
D O I
10.3390/v13061033
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Feline panleukopenia is a severe disease of cats caused by feline parvovirus (FPV), and marginally canine parvovirus (CPV). Despite being less rapid than CPV, FPV evolution deserves attention, especially since outbreaks of particular severity are currently reported. This apparently different virulence needs monitoring from genetic and clinical points of view. This manuscript explored FPV molecular epidemiology at both Italian and international levels and the possible association between viral phylogeny and disease severity. Sequences from clinical cases of feline panleukopenia in Italy were obtained from 2011 to 2019, and the etiological agent was characterized, distinguishing FPV from CPV. Phylogenetic and phylodynamic analyses were conducted on Italian and international sequences. Moreover, the association between the viral sequence and clinical variables was evaluated on a group of highly characterized patients. After its origin in the 1920s, FPV showed a constant population size until a more recent expansion since 2000. Few long-distance introduction events characterized FPV spreading, however, most of its evolution occurred locally. Although without a strong statistical association, several clinical variables appeared influenced by viral phylogeny, suggesting a differential virulence potentially characterizing FPV strains. These results stress the importance of the continuous study of viral evolution and its repercussions on the disease clinical aspects.
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页数:11
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