Pharmacologic inhibition of 11β-HSD1 improves measures of metabolic Syndrome without impairment of HPA function in DIO mice

被引：0
|
作者：
Rosko, K
Bradbury, M
Balkovec, JM
Gagen, K
Olson, SH
Gorski, J
Yang, LM
Robertson, N
Chapman, D
Dogariu, A
Thieringer, R
Vosatka, A
Strack, AM
Metzger, J
机构：
[1] Merck Res Labs, Rahway, NJ 07065 USA
[2] Neurocrine Biosci, San Diego, CA 92130 USA
来源：
FASEB JOURNAL | 2005年 / 19卷 / 04期
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：A189 / A189
页数：1
相关论文
共 45 条
  • [31] Inhibition of 11β-HSD1 Ameliorates Cognition and Molecular Detrimental Changes after Chronic Mild Stress in SAMP8 Mice
    Puigoriol-Illamola, Dolors
    Companys-Alemany, Julia
    McGuire, Kris
    Homer, Natalie Z. M.
    Leiva, Rosana
    Vazquez, Santiago
    Mole, Damian J.
    Grinan-Ferre, Christian
    Pallas, Merce
    PHARMACEUTICALS, 2021, 14 (10)
  • [32] WCC 7-Medication for the fast food nation: Bicyclo[2.2.2]octyltriazole inhibitors of 11 β-HSD1 for the treatment of metabolic syndrome
    Maletic, Milana
    Leeman, Aaron
    Waddell, Sherman T.
    Balkovec, James M.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 238
  • [33] G6PT-H6PDH-11βHSD1 triad in the liver and its implication in the pathomechanism of the metabolic syndrome
    Ibolya Czegle
    Miklós Csala
    József Mandl
    Angelo Benedetti
    István Karádi
    Gábor Bánhegyi
    World Journal of Hepatology, 2012, 4 (04) : 129 - 138
  • [34] Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11β-HSD1:: Novel therapeutic agents for the treatment of metabolic syndrome
    Gu, X
    Dragovic, J
    Koo, GC
    Koprak, SL
    LeGrand, C
    Mundt, SS
    Shah, K
    Springer, MS
    Tan, EY
    Thieringer, R
    Hermanowski-Vosatka, A
    Zokian, HJ
    Balkovec, JM
    Waddell, ST
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (23) : 5266 - 5269
  • [35] G6PT-H6PDH-11 beta HSD1 triad in the liver and its implication in the pathomechanism of the metabolic syndrome
    Czegle, Ibolya
    Csala, Miklos
    Mandl, Jozsef
    Benedetti, Angelo
    Karadi, Istvan
    Banhegyi, Gabor
    WORLD JOURNAL OF HEPATOLOGY, 2012, 4 (04) : 129 - 138
  • [36] Sub-chronic administration of the 11β-HSD1 inhibitor, carbenoxolone, improves glucose tolerance and insulin sensitivity in mice with diet-induced obesity
    Taylor, Ashley
    Irwin, Nigel
    McKillop, Aine M.
    Flatt, Peter R.
    Gault, Victor A.
    BIOLOGICAL CHEMISTRY, 2008, 389 (04) : 441 - 445
  • [37] Increased Angiogenesis Protects against Adipose Hypoxia and Fibrosis in Metabolic Disease-resistant 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD1)-deficient Mice
    Michailidou, Zoi
    Turban, Sophie
    Miller, Eileen
    Zou, Xiantong
    Schrader, Joerg
    Ratcliffe, Peter J.
    Hadoke, Patrick W. F.
    Walker, Brian R.
    Iredale, John P.
    Morton, Nicholas M.
    Seckl, Jonathan R.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (06) : 4188 - 4197
  • [38] Generation of porcine fibroblasts overexpressing 11β-HSD1 with adipose tissue-specific aP2 promoter as a porcine model of metabolic syndrome
    Jung, Eui-Man
    An, Beum-Soo
    Kim, Yu-Kyung
    Jeong, Young-Hee
    Hwang, Woo-Suk
    Jeung, Eui-Bae
    MOLECULAR MEDICINE REPORTS, 2013, 8 (03) : 751 - 756
  • [39] Triterpene saponins from Barringtonia acutangula (L.) Gaertn as a potent inhibitor of 11β-HSD1 for type 2 diabetes mellitus, obesity, and metabolic syndrome
    Vishal Shivalingappa Patil
    Nayeem A. Khatib
    Clinical Phytoscience, 6 (1)
  • [40] In search of selective 11β-HSD type 1 inhibitors without nephrotoxicity: An approach to resolve the metabolic syndrome by virtual based screening
    Patel, Harun
    Dhangar, Kiran
    Sonawane, Yogesh
    Surana, Sanjay
    Karpoormath, Rajshekhar
    Thapliyal, Neeta
    Shaikh, Mahamadhanif
    Noolvi, Malleshappa
    Jagtap, Rakesh
    ARABIAN JOURNAL OF CHEMISTRY, 2018, 11 (02) : 221 - 232
12345