Pharmacologic inhibition of 11β-HSD1 improves measures of metabolic Syndrome without impairment of HPA function in DIO mice

被引:0
|
作者
Rosko, K
Bradbury, M
Balkovec, JM
Gagen, K
Olson, SH
Gorski, J
Yang, LM
Robertson, N
Chapman, D
Dogariu, A
Thieringer, R
Vosatka, A
Strack, AM
Metzger, J
机构
[1] Merck Res Labs, Rahway, NJ 07065 USA
[2] Neurocrine Biosci, San Diego, CA 92130 USA
来源
FASEB JOURNAL | 2005年 / 19卷 / 04期
关键词
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:A189 / A189
页数:1
相关论文
共 45 条
  • [21] 11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature
    Luo, Mingjuan J.
    Thieringer, Rolf
    Springer, Martin S.
    Wright, Samuel D.
    Hermanowski-Vosatka, Anne
    Plump, Andrew
    Balkovec, James M.
    Cheng, Kang
    Ding, Gloria J.
    Kawka, Douglas W.
    Koo, Gloria C.
    Le Grand, Cheryl B.
    Luo, Qi
    Maletic, Milana M.
    Malkowitz, Lorraine
    Shah, Kashmira
    Singer, Irwin
    Waddell, Sherman T.
    Wu, Kenneth K.
    Yuan, Jeffrey
    Zhu, Jun
    Stepaniants, Serguei
    Yang, Xia
    Lum, Pek Yee
    Wang, I-Ming
    PHYSIOLOGICAL GENOMICS, 2013, 45 (01) : 47 - 57
  • [22] 11β-HSD1, Inflammation, Metabolic Disease and Age-related Cognitive (dys)Function
    Karen E. Chapman
    Jonathan R. Seckl
    Neurochemical Research, 2008, 33 : 624 - 636
  • [23] 11β-HSD1, inflammation, metabolic disease and age-related cognitive (dys)Function
    Chapman, Karen E.
    Seckl, Jonathan R.
    NEUROCHEMICAL RESEARCH, 2008, 33 (04) : 624 - 636
  • [24] Atheroprotection Induced by Selective 11β-Hydroxysteroid Dehydrogenase Type 1 (11βHSD1) Inhibition in Male ApoE-/-Mice
    Huebschle, Thomas
    Falk, Eugen
    Glien, Maike
    Sadowski, Thorsten
    Ruetten, Hartmut
    DIABETES, 2011, 60 : A105 - A105
  • [25] Increased gene expression for 11β-HSD1 and selected adipokines in subcutaneous adipose tissue of subjects with several features of metabolic syndrome without prediabetes
    Gasperikova, D
    Radikova, Z
    Skopkova, M
    Penesova, A
    Imrich, R
    Vlcek, M
    Koska, J
    Sebokova, E
    Klimes, I
    DIABETOLOGIA, 2005, 48 : A213 - A213
  • [26] Male 11β-HSD1 Knockout Mice Fed Trans-Fats and Fructose Are Not Protected From Metabolic Syndrome or Nonalcoholic Fatty Liver Disease
    Larner, Dean P.
    Morgan, Stuart A.
    Gathercole, Laura L.
    Doig, Craig L.
    Guest, Phil
    Weston, Christopher
    Hazeldine, Jon
    Tomlinson, Jeremy W.
    Stewart, Paul M.
    Lavery, Gareth G.
    ENDOCRINOLOGY, 2016, 157 (09) : 3493 - 3504
  • [27] 11βHSD1 Inhibition with AZD4017 Improves Lipid Profiles and Lean Muscle Mass in Idiopathic Intracranial Hypertension
    Hardy, Rowan S.
    Botfield, Hannah
    Markey, Keira
    Mitchell, James L.
    Alimajstorovic, Zerin
    Westgate, Connar S. J.
    Sagmeister, Michael
    Fairclough, Rebecca J.
    Ottridge, Ryan S.
    Yiangou, Andreas
    Storbeck, Karl-Heinz H.
    Taylor, Angela E.
    Gilligan, Lorna C.
    Arlt, Wiebke
    Stewart, Paul M.
    Tomlinson, Jeremy W.
    Mollan, Susan P.
    Lavery, Gareth G.
    Sinclair, Alexandra J.
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2021, 106 (01): : 174 - 187
  • [28] 11β-HSD1 inhibition improves triglyceridemia through reduced liver VLDL secretion and partitions lipids toward oxidative tissues
    Berthiaume, Magalie
    Laplante, Mathieu
    Festuccia, William T.
    Cianflone, Katherine
    Turcotte, Lorraine P.
    Joanisse, Denis R.
    Olivecrona, Gunilla
    Thieringer, Rolf
    Deshaies, Yves
    AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2007, 293 (04): : E1045 - E1052
  • [29] Enhanced neovascularisation does not account for preservation of cardiac function by 11βHSD1 inhibition in a pig model of myocardial infarction
    Al Disi, Sara
    Ascione, Raimondo
    Johnson, Tom
    Sammut, Eva
    Bruno, Vito Domenico
    Khan, Shazia
    Singh, Trisha
    Baz-Lopez, Daniel
    James, Carol-Ann
    Walker, Brian
    Mills, Nicholas
    Webster, Scott
    Freeman, Adrian
    Whittaker, Andrew
    Andrew, Ruth
    Gray, Gillian
    CIRCULATION RESEARCH, 2024, 135
  • [30] Inhibition of 11β-HSD1 activity decreases blood pressure, improves glucose tolerance, and reduces microalbuminuria in SHR or obese Zucker rat
    Schnackenberg, Christine G.
    Doe, Chris P.
    Costell, Melissa H.
    Turner, Ashley R.
    Cui, Jianqi
    Bentley, Ross
    Maniscalco, Kristeen
    Eybye, Marianne E.
    Willette, Robert N.
    Yue, Tian-Li
    HYPERTENSION, 2007, 50 (04) : E87 - E87