T-independent immune response: New aspects of B cell biology

被引：303

作者：

Fagarasan, S ^{[1
]}

Honjo, T ^{[1
]}

机构：

[1] Kyoto Univ, Fac Med, Dept Med Chem, Sakyo Ku, Kyoto 6068501, Japan

来源：

SCIENCE | 2000年 / 290卷 / 5489期

关键词：

D O I：

10.1126/science.290.5489.89

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recent results emphasize the roles of T-independent antibody response in humoral defenses, for which B1 cells and marginal zone B cells are mostly responsible. We discuss how these cells are activated, migrate, and differentiate into antibody-producing cells in various Lymphoid tissues. Based on recent findings in each of these areas of B cell biology, we propose a possible mechanism for peripheral tolerance of autoreactive B cells at target organs.

引用

页码：89 / 92

页数：4

共 28 条

[1]

[Anonymous], UNPUB

[2] Monoclonal immunoglobulin a derived from peritoneal B cells is encoded by both germ line and somatically mutated V-H genes and is reactive with commensal bacteria [J].

Bos, NA ;

Bun, JCAM ;

Popma, SH ;

Cebra, ER ;

Deenen, GJ ;

vanderCammen, MJF ;

Kroese, FGM ;

Cebra, JJ .

INFECTION AND IMMUNITY, 1996, 64 (02) :616-623

[3] C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity [J].

Dempsey, PW ;

Allison, MED ;

Akkaraju, S ;

Goodnow, CC ;

Fearon, DT .

SCIENCE, 1996, 271 (5247) :348-350

[4] Alymphoplasia (aly)-type nuclear factor κB-inducing kinase (NIK) causes defects in secondary lymphoid tissue chemokine receptor signaling and homing of peritoneal cells to the gut-associated lymphatic tissue system [J].

Fagarasan, S ;

Shinkura, R ;

Kamata, T ;

Nogaki, F ;

Ikuta, K ;

Tashiro, K ;

Honjo, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (09) :1477-1486

[5]

Fagarasan S, 2000, IMMUNOL REV, V176, P205

[6]

FREEMAN GJ, IN PRESS J EXP MED

[7] TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease [J].

Gross, JA ;

Johnston, J ;

Mudri, S ;

Enselman, R ;

Dillon, SR ;

Madden, K ;

Xu, WF ;

Parrish-Novak, J ;

Foster, D ;

Lofton-Day, C ;

Moore, M ;

Littau, A ;

Grossman, A ;

Haugen, H ;

Foley, K ;

Blumberg, H ;

Harrison, K ;

Kindsvogel, W ;

Clegg, CH .

NATURE, 2000, 404 (6781) :995-999

[8] Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response [J].

Guinamard, R ;

Okigaki, M ;

Schlessinger, J ;

Ravetch, JV .

NATURE IMMUNOLOGY, 2000, 1 (01) :31-36

[9] THE LY-1-B CELL SUBPOPULATION IN NORMAL, IMMUNODEFECTIVE, AND AUTOIMMUNE MICE [J].

HAYAKAWA, K ;

HARDY, RR ;

PARKS, DR ;

HERZENBERG, LA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1983, 157 (01) :202-218

[10] INDUCED EXPRESSION OF PD-1, A NOVEL MEMBER OF THE IMMUNOGLOBULIN GENE SUPERFAMILY, UPON PROGRAMMED CELL-DEATH [J].

ISHIDA, Y ;

AGATA, Y ;

SHIBAHARA, K ;

HONJO, T .

EMBO JOURNAL, 1992, 11 (11) :3887-3895

← 1 2 3 →