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Enhancement of anti-tumor immunity by photodynamic therapy
被引:139
作者:
Gollnick, Sandra O.
[1
,2
]
Brackett, Craig M.
[1
]
机构:
[1] Roswell Pk Canc Inst, Dept Immunol, Buffalo, NY 14263 USA
[2] Roswell Pk Canc Inst, Dept Cell Stress Biol, Buffalo, NY 14263 USA
关键词:
PDT;
Neutrophil;
Vaccine;
T cell;
COLONY-STIMULATING FACTOR;
HEAT-SHOCK PROTEINS;
TOLL-LIKE RECEPTORS;
CD8;
T-CELLS;
DENDRITIC CELLS;
LYMPH-NODES;
EXPRESSION;
NEUTROPHILS;
CANCER;
TUMOR;
D O I:
10.1007/s12026-009-8119-4
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Photodynamic therapy (PDT) is an FDA-approved modality that rapidly eliminates local tumors, resulting in cure of early disease and palliation of advanced disease. PDT was originally considered to be a local treatment; however, both pre-clinical and clinical studies have shown that local PDT treatment of tumors can enhance systemic anti-tumor immunity. The current state of investigations into the ability of PDT to enhance anti-tumor immunity, the mechanisms behind this enhancement and the future of PDT as an immunotherapy are addressed in this review.
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页码:216 / 226
页数:11
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