Enhancement of anti-tumor immunity by photodynamic therapy

被引:137
作者
Gollnick, Sandra O. [1 ,2 ]
Brackett, Craig M. [1 ]
机构
[1] Roswell Pk Canc Inst, Dept Immunol, Buffalo, NY 14263 USA
[2] Roswell Pk Canc Inst, Dept Cell Stress Biol, Buffalo, NY 14263 USA
关键词
PDT; Neutrophil; Vaccine; T cell; COLONY-STIMULATING FACTOR; HEAT-SHOCK PROTEINS; TOLL-LIKE RECEPTORS; CD8; T-CELLS; DENDRITIC CELLS; LYMPH-NODES; EXPRESSION; NEUTROPHILS; CANCER; TUMOR;
D O I
10.1007/s12026-009-8119-4
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Photodynamic therapy (PDT) is an FDA-approved modality that rapidly eliminates local tumors, resulting in cure of early disease and palliation of advanced disease. PDT was originally considered to be a local treatment; however, both pre-clinical and clinical studies have shown that local PDT treatment of tumors can enhance systemic anti-tumor immunity. The current state of investigations into the ability of PDT to enhance anti-tumor immunity, the mechanisms behind this enhancement and the future of PDT as an immunotherapy are addressed in this review.
引用
收藏
页码:216 / 226
页数:11
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