Micellization of cationic gemini surfactants with various counterions and their interaction with DNA in aqueous solution

被引:87
作者
Jiang, N
Li, PX
Wang, YL [1 ]
Wang, JB
Yan, HK
Thomas, RK
机构
[1] Chinese Acad Sci, Inst Chem, Key Lab Colloid & Interface Sci, Ctr Mol Sci, Beijing 100080, Peoples R China
[2] Univ Oxford, Phys & Theoret Chem Lab, Oxford OX1 3QZ, England
关键词
D O I
10.1021/jp0488057
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
The micellization of six cationic gemini surfactants with various counterions, [C12H25(CH3)(2)N(CH2)(6)N-(CH3)(2)C12H25]X-2, designated as C12C6C12X2, with X = F-, Cl-, Br-, Ac-, NO3-, and (1)/2SO42- in aqueous solutions has been investigated by isothermal titration microcalorimetry (ITC) and conductivity measurements. The interaction of these surfactants with DNA in aqueous solutions has also been investigated by isothermal titration microcalorimetry. The critical micelle concentration (CMC) and the degree of micellar ionization (alpha), the critical aggregation concentration (CAC), the saturation concentration (C-2) of the aggregation, and the associated thermodynamic parameters were determined. The nature of the counterion significantly affects the processes of both micellization and aggregation. The trends for aggregation basically follow the Hofmeister (lyotropic) series, but the pattern of the variation of the enthalpy of aggregation often revealed a more complex behavior. Among the counterions examined, SO42- is the most effective anion for decreasing the CMC (or CAC). Both aggregation processes are mainly entropy-driven since the values of the entropy changes multiplied by temperature are much larger than the absolute values of the enthalpy changes. The binding of micelles to DNA is strongly dominated by the positive entropy gain on release of the small counterions from the micelles and from DNA. The interaction of all of the surfactants with DNA was dependent on the DNA concentration and may be associated with each micelle interacting with more than one DNA molecule.
引用
收藏
页码:15385 / 15391
页数:7
相关论文
共 53 条
  • [1] COUNTERIONS AND MICELLE SIZE .1. LIGHT SCATTERING BY SOLUTIONS OF DODECYLTRIMETHYLAMMONIUM SALTS
    ANACKER, EW
    GHOSE, HM
    [J]. JOURNAL OF PHYSICAL CHEMISTRY, 1963, 67 (08) : 1713 - &
  • [2] Thermodynamics of hydrophobic interaction of dissymmetric gemini surfactants in aqueous solutions
    Bai, GY
    Wang, JB
    Wang, YJ
    Yan, H
    Thomas, RK
    [J]. JOURNAL OF PHYSICAL CHEMISTRY B, 2002, 106 (26) : 6614 - 6616
  • [3] Thermodynamics of interaction between cationic gemini surfactants and hydrophobically modified polymers in aqueous solutions
    Bai, GY
    Wang, YJ
    Yan, HK
    Thomas, RK
    Kwak, JCT
    [J]. JOURNAL OF PHYSICAL CHEMISTRY B, 2002, 106 (09) : 2153 - 2159
  • [4] Microcalorimetric studies on the thermodynamic properties of cationic gemini surfactants
    Bai, GY
    Yan, HK
    Thomas, RK
    [J]. LANGMUIR, 2001, 17 (15) : 4501 - 4504
  • [5] Interaction of DNA with cationic vesicles: A calorimetric study
    Barreleiro, PCA
    Olofsson, G
    Alexandridis, P
    [J]. JOURNAL OF PHYSICAL CHEMISTRY B, 2000, 104 (32) : 7795 - 7802
  • [6] Transfection mediated by gemini surfactants: Engineered escape from the endosomal compartment
    Bell, PC
    Bergsma, M
    Dolbnya, IP
    Bras, W
    Stuart, MCA
    Rowan, AE
    Feiters, MC
    Engberts, JBFN
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (06) : 1551 - 1558
  • [7] Gemini surfactant/DNA complex monolayers at the air-water interface: Effect of surfactant structure on the assembly, stability, and topography of monolayers
    Chen, XD
    Wang, JB
    Shen, N
    Luo, YH
    Li, L
    Liu, MH
    Thomas, RK
    [J]. LANGMUIR, 2002, 18 (16) : 6222 - 6228
  • [8] ALKYL SULPHATES .1. CRITICAL MICELLE CONCENTRATIONS OF THE SODIUM SALTS
    EVANS, HC
    [J]. JOURNAL OF THE CHEMICAL SOCIETY, 1956, (MAR): : 579 - 586
  • [9] Two-dimensional condensation of DNA molecules on cationic lipid membranes
    Fang, Y
    Yang, J
    [J]. JOURNAL OF PHYSICAL CHEMISTRY B, 1997, 101 (03): : 441 - 449
  • [10] ALKANEDIYL-ALPHA,OMEGA-BIS(DIMETHYLALKYLAMMONIUM BROMIDE) SURFACTANTS .4. ULTRASONIC-ABSORPTION STUDIES OF AMPHIPHILE EXCHANGE BETWEEN MICELLES AND BULK PHASE IN AQUEOUS MICELLAR SOLUTIONS
    FRINDI, M
    MICHELS, B
    LEVY, H
    ZANA, R
    [J]. LANGMUIR, 1994, 10 (04) : 1140 - 1145