Single High-Dose Vitamin D Supplementation as an Approach for Reducing Ultramarathon-Induced Inflammation: A Double-Blind Randomized Controlled Trial

被引:15
作者
Mieszkowski, Jan [1 ,2 ]
Borkowska, Andzelika [3 ]
Stankiewicz, Blaiej [4 ]
Kochanowicz, Andrzej [1 ]
Niespodzinski, Bartlomiej [5 ]
Surmiak, Marcin [6 ]
Waldzinski, Tomasz [7 ]
Rola, Rafal [8 ,9 ]
Petr, Miroslav [2 ]
Antosiewicz, Jedrzej [3 ]
机构
[1] Gdansk Univ Phys Educ & Sport, Dept Gymnast & Dance, PL-80336 Gdansk, Poland
[2] Charles Univ Prague, Fac Phys Educ & Sport, Prague 16252, Czech Republic
[3] Med Univ Gdansk, Dept Bioenerget & Physiol Exercise, PL-85064 Gdansk, Poland
[4] Kazimierz Wielki Univ, Inst Phys Educ, Dept Biomed Basis Phys Educ, PL-85064 Bydgoszcz, Poland
[5] Kazimierz Wielki Univ, Inst Phys Educ, Dept Anat & Biomech, PL-85064 Bydgoszcz, Poland
[6] Jagiellonian Univ, Dept Internal Med, Med Coll, PL-31007 Krakow, Poland
[7] Lomza State Univ Appl Sci, Fac Hlth Sci, PL-18400 Lomza, Poland
[8] Masdiag Sp ZOO, PL-01882 Warsaw, Poland
[9] Nicolaus Copernicus Univ, Fac Chem, Chair Environm Chem & Bioanalyt, PL-87100 Torun, Poland
关键词
IL-6; resistin; inflammation; ultramarathon; skeletal muscle damage; vitamin D; PLASMA CYTOKINES; SKELETAL-MUSCLE; EXERCISE; BIOMARKERS; EXPRESSION; IBUPROFEN; RODENTS;
D O I
10.3390/nu13041280
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Purpose: A growing number of studies indicate the importance of vitamin D supplementation for sports performance. However, the effects of a single high-dose vitamin D supplementation on ultramarathon-induced inflammation have not been investigated. We here analyzed the effect of a single high-dose vitamin D supplementation on the inflammatory marker levels in ultramarathon runners after an ultramarathon run (maximal run 240 km). Methods: In the study, 35 runners (amateurs) were assigned into two groups: single high-dose vitamin D supplementation group, administered vitamin D (150,000 IU) in vegetable oil 24 h before the start of the run (n = 16); and placebo group (n = 19). Blood was collected for analysis 24 h before, immediately after, and 24 h after the run. Results: Serum 25(OH)D levels were significantly increased after the ultramarathon in both groups. The increase was greater in the vitamin D group than in the control group. Based on post-hoc and other analyses, the increase in interleukin 6 and 10, and resistin levels immediately after the run was significantly higher in runners in the control group than that in those in the supplementation group. Leptin, oncostatin M, and metalloproteinase tissue inhibitor levels were significantly decreased in both groups after the run, regardless of the supplementation. Conclusions: Ultramarathon significantly increases the serum 25(OH)D levels. Attenuation of changes in interleukin levels upon vitamin D supplementation confirmed that vitamin D has anti-inflammatory effect on exercise-induced inflammation.
引用
收藏
页数:13
相关论文
共 37 条
[1]   Leptin Activates Human B Cells to Secrete TNF-α, IL-6, and IL-10 via JAK2/STAT3 and p38MAPK/ERK1/2 Signaling Pathway [J].
Agrawal, Sudhanshu ;
Gollapudi, Sastry ;
Su, Houfen ;
Gupta, Sudhir .
JOURNAL OF CLINICAL IMMUNOLOGY, 2011, 31 (03) :472-478
[2]   Requirement of TLR2-mediated signaling for the induction of IL-15 gene expression in human monocytic cells by HSV-1 [J].
Ahmad, Rasheed ;
El Bassam, Souad ;
Cordeiro, Paulo ;
Menezes, Jose .
BLOOD, 2008, 112 (06) :2360-2368
[3]   Hypovitaminosis D associations with adverse metabolic parameters are accentuated in patients with Type 2 diabetes mellitus: A body mass index-independent role of adiponectin? [J].
Al-Daghri, N. M. ;
Al-Attas, O. S. ;
Alokail, M. S. ;
Alkharfy, K. M. ;
Al-Othman, A. ;
Draz, H. M. ;
Yakout, S. M. ;
Al-Saleh, Y. ;
Al-Yousef, M. ;
Sabico, S. ;
Clerici, M. ;
Chrousos, G. P. .
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2013, 36 (01) :1-6
[4]   Focus on Vitamin D, Inflammation and Type 2 Diabetes [J].
Andrade Chagas, Carlos Eduardo ;
Borges, Maria Carolina ;
Martini, Lgia Araujo ;
Rogero, Marcelo Macedo .
NUTRIENTS, 2012, 4 (01) :52-67
[5]   Role of Resistin in Insulin Sensitivity in Rodents and Humans [J].
Barnes, K. M. ;
Miner, J. L. .
CURRENT PROTEIN & PEPTIDE SCIENCE, 2009, 10 (01) :96-107
[6]   Serum 25-hydroxyvitamin D levels are inversely associated with systemic inflammation in severe obese subjects [J].
Bellia, Alfonso ;
Garcovich, Caterina ;
D'Adamo, Monica ;
Lombardo, Mauro ;
Tesauro, Manfredi ;
Donadel, Giulia ;
Gentileschi, Paolo ;
Lauro, Davide ;
Federici, Massimo ;
Lauro, Renato ;
Sbraccia, Paolo .
INTERNAL AND EMERGENCY MEDICINE, 2013, 8 (01) :33-40
[7]   Role of brain IL-1β on fatigue after exercise-induced muscle damage [J].
Carmichael, Martin D. ;
Davis, J. Mark ;
Murphy, E. Angela ;
Brown, Adrienne S. ;
Carson, James A. ;
Mayer, Eugene P. ;
Ghaffar, Abdul .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2006, 291 (05) :R1344-R1348
[8]   Vitamin D supplementation during exercise training does not alter inflammatory biomarkers in overweight and obese subjects [J].
Carrillo, Andres E. ;
Flynn, Michael G. ;
Pinkston, Catherine ;
Markofski, Melissa M. ;
Jiang, Yan ;
Donkin, Shawn S. ;
Teegarden, Dorothy .
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 2012, 112 (08) :3045-3052
[9]   Vitamin D3 supplementation modulates inflammatory responses from the muscle damage induced by high-intensity exercise in SD rats [J].
Choi, Munji ;
Park, Hyon ;
Cho, Seongsuk ;
Lee, Myoungsook .
CYTOKINE, 2013, 63 (01) :27-35
[10]   A MEANS OF ASSESSING MAXIMAL OXYGEN INTAKE - CORRELATION BETWEEN FIELD AND TREADMILL TESTING [J].
COOPER, KH .
JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1968, 203 (03) :201-&