Propagated infra-slow intrinsic brain activity reorganizes across wake and slow wave sleep

被引:86
作者
Mitra, Anish [1 ]
Snyder, Abraham Z. [1 ,2 ]
Tagliazucchi, Enzo [3 ,4 ]
Laufs, Helmut [4 ,5 ]
Raichle, Marcus E. [1 ,2 ]
机构
[1] Washington Univ, Dept Radiol, St Louis, MO USA
[2] Washington Univ, Dept Neurol, St Louis, MO USA
[3] Univ Kiel, Inst Med Psychol, Kiel, Germany
[4] Goethe Univ Frankfurt, Brain Imaging Ctr, Dept Neurol, D-60054 Frankfurt, Germany
[5] Univ Kiel, Dept Neurol, Kiel, Germany
基金
美国国家卫生研究院;
关键词
LESS-THAN-1 HZ OSCILLATION; DEFAULT MODE NETWORK; FUNCTIONAL CONNECTIVITY; CELLULAR MECHANISMS; GENERAL-ANESTHESIA; CORTICAL ACTIVITY; LOW-FREQUENCY; MEMORY; DYNAMICS; NEURONS;
D O I
10.7554/eLife.10781
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Propagation of slow intrinsic brain activity has been widely observed in electrophysiogical studies of slow wave sleep (SWS). However, in human resting state fMRI (rs-fMRI), intrinsic activity has been understood predominantly in terms of zero-lag temporal synchrony (functional connectivity) within systems known as resting state networks (RSNs). Prior rs-fMRI studies have found that RSNs are generally preserved across wake and sleep. Here, we use a recently developed analysis technique to study propagation of infra-slow intrinsic blood oxygen level dependent (BOLD) signals in normal adults during wake and SWS. This analysis reveals marked changes in propagation patterns in SWS vs. wake. Broadly, ordered propagation is preserved within traditionally defined RSNs but lost between RSNs. Additionally, propagation between cerebral cortex and subcortical structures reverses directions, and intra-cortical propagation becomes reorganized, especially in visual and sensorimotor cortices. These findings show that propagated rs-fMRI activity informs theoretical accounts of the neural functions of sleep.
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页数:19
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