Upwards Drift of Cerebrospinal Fluid Amyloid-β 42 Over Twelve Years in a Consecutive Clinical Cohort

被引：7

作者：

Simonsen, Anja Hviid ^{[1
]}

Musaeus, Christian Sandoe ^{[1
]}

Christensen, Gitte Lund ^{[2
]}

Hasselbalch, Steen Gregers ^{[1
]}

Waldemar, Gunhild ^{[1
]}

机构：

[1] Univ Copenhagen, Rigshosp, Danish Dementia Res Ctr, Dept Neurol, Copenhagen, Denmark

[2] Univ Copenhagen, Rigshosp Glostrup, Ctr Diagnost Invest, Dept Clin Chem, Copenhagen, Denmark

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2021年 / 81卷 / 04期

关键词：

Alzheimer's disease; amyloid-beta; 42; biomarker; cerebrospinal fluid; ALZHEIMERS-DISEASE; RECOMMENDATIONS; BIOMARKERS; DIAGNOSIS; DEMENTIA;

D O I：

10.3233/JAD-201506

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Amyloid-beta 1-42 (A beta(1-42)) measured in the cerebrospinal fluid (CSF) can be used as a diagnostic biomarker for Alzheimer's disease (AD) but an upward drift when using the INNOTEST ELISA has been suggested. We investigated the upwards drift of A beta(1-42) levels over a period of twelve years in a consecutive memory clinic cohort. We found a significant increase in A beta(1-42) from 2008 to 2019 independent of changes in tau. New methods for the quantification of CSF A beta(1-42) levels are being implemented but awareness of this upwards drift is crucial during the diagnostic work-up and when selecting historical samples for research.

引用

页码：1369 / 1373

页数：5

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