Cellulose-graft-poly(methyl methacrylate) nanoparticles with high biocompatibility for hydrophobic anti-cancer drug delivery

被引：30

作者：

Dai, Lin ^{[1
,2
]}

Si, Chuan-Ling ^{[1
]}

机构：

[1] Tianjin Univ Sci & Technol, Tianjin Key Lab Pulp & Paper, Tianjin 300457, Peoples R China

[2] South China Univ Technol, State Key Lab Pulp & Paper Engn, Guangzhou 510640, Guangdong, Peoples R China

来源：

MATERIALS LETTERS | 2017年 / 207卷

关键词：

Cellulose; Nanoparticles; Biomaterials; Drug delivery; Betulinic acid; DEGRADATION; CELLULOSE; POLYMER;

D O I：

10.1016/j.matlet.2017.07.090

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Cellulose-based nanoparticles have very fine application foreground in drug delivery. Herein, a new cellulose- hydrophobic polymer hybrid nanoparticle (CE-g-PMMA NPs) with low polydispersity index has been builted by an easy method. The obtained nanoparticles with 2029 wt% of PMMA possessed appropriate size (similar to 120 nm), high drug loading efficiency (similar to 20 wt% BA) and a slow drug release rate. The CE-gPMMA NPs not only showed excellent biocompatibility, More important, compared to the free betulinic acid (BA), the BA-loaded CE-g-PMMA NPs significantly improved the cellular cytotoxicity and reduced the risk of side-effect. This cellulose- based "green nanoparticles" showed highly potential for hydrophobic anti- cancer drug delivery. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：213 / 216

页数：4

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