Merozoite surface proteins of the malaria parasite: The MSP1 complex and the MSP7 family

被引:57
|
作者
Kadekoppala, Madhusudan [1 ]
Holder, Anthony A. [1 ]
机构
[1] Natl Inst Med Res, MRC, Div Parasitol, London NW7 1AA, England
基金
英国医学研究理事会; 美国国家卫生研究院;
关键词
Malaria; Plasmodium falciparum; Merozoite surface proteins; Red blood cell invasion; PLASMODIUM-FALCIPARUM MEROZOITES; ANCHORED MEMBRANE-PROTEINS; HUMAN-ERYTHROCYTES; MULTIGENE FAMILY; LIFE-CYCLE; INVASION; GENE; IDENTIFICATION; EXPRESSION; PRECURSOR;
D O I
10.1016/j.ijpara.2010.04.008
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
The first interaction between the malaria merozoite and the red blood cell it will invade is mediated by molecules on the surface of the two cells. The Plasmodium falciparum merozoite surface protein (MSP)1 complex that contains MSP1 and two other parasite proteins, MSP6 and MSP7, is likely to be an important component in this process. This article reviews the role of the MSP1 complex in the biology of the host parasite interface with a focus on MSP7 and related proteins that are coded by gene families in each of the different Plasmodium spp. (C) 2010 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:1155 / 1161
页数:7
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