Consensus guidelines for antifungal prophylaxis in haematological malignancy and haemopoietic stem cell transplantation, 2014

被引：91

作者：

Fleming, S. ^{[1
]}

Yannakou, C. K. ^{[2
,3
]}

Haeusler, G. M. ^{[4
,5
,6
]}

Clark, J. ^{[7
]}

Grigg, A. ^{[8
,9
]}

Heath, C. H. ^{[10
,11
]}

Bajel, A. ^{[2
,3
]}

van Hal, S. J. ^{[12
]}

Chen, S. C. ^{[13
,14
,15
]}

Milliken, S. T. ^{[16
,17
,18
]}

Morrissey, C. O. ^{[19
,20
,21
]}

Tam, C. S. ^{[9
,22
]}

Szer, J. ^{[2
,3
,9
]}

Weinkove, R. ^{[23
,24
]}

Slavin, M. A. ^{[4
,9
,25
]}

机构：

[1] Alfred Hlth, Malignant Haematol & Stem Cell Transplantat Serv, Prahran, Vic, Australia

[2] Royal Melbourne Hosp, Dept Clin Haematol, Parkville, Vic 3050, Australia

[3] Royal Melbourne Hosp, Bone Marrow Transplant Serv, Parkville, Vic 3050, Australia

[4] Peter MacCallum Canc Ctr, Dept Infect Dis & Infect Control, East Melbourne, Vic 8006, Australia

[5] Monash Childrens Hosp, Dept Paediat Infect Dis, Monash Hlth, Clayton, Vic, Australia

[6] Paediat Integrated Canc Serv, Parkville, Vic, Australia

[7] Royal Childrens Hosp Brisbane, Infect Management & Prevent Serv, Queensland Hlth, Herston, Qld, Australia

[8] Austin Hlth, Dept Clin Haematol, Heidelberg, Vic, Australia

[9] Univ Melbourne, Sch Med, Melbourne, Vic, Australia

[10] Royal Perth Hosp, Dept Microbiol & Infect Dis, Perth, WA 6001, Australia

[11] Univ Western Australia, RPH Unit, Sch Med & Pharmacol, Perth, WA 6009, Australia

[12] Royal Prince Alfred Hosp, Dept Microbiol & Infect Dis, Camperdown, NSW 2050, Australia

[13] ICPMR Pathol West, Ctr Infect Dis & Microbiol Lab Serv, Westmead, NSW, Australia

[14] Westmead Hosp, Dept Infect Dis, Westmead, NSW 2145, Australia

[15] Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia

[16] St Vincents Hosp, Dept Haematol, Darlinghurst, NSW 2010, Australia

[17] Univ NSW, Fac Med, Kensington, NSW, Australia

[18] Univ NSW, Fac Pathol, Kensington, NSW, Australia

[19] Alfred Hlth, Dept Infect Dis, Prahran, Vic, Australia

[20] Monash Univ, Prahran, Vic, Australia

[21] Alfred Hlth, Dept Clin Haematol, Prahran, Vic, Australia

[22] Peter MacCallum Canc Ctr, Dept Haematol, East Melbourne, Vic 8006, Australia

[23] Capital & Coast Dist Hlth Board, Wellington Blood & Canc Ctr, Wellington, New Zealand

[24] Malaghan Inst Med Res, Vaccine Res Grp, Wellington, New Zealand

[25] Doherty Inst Infect & Immun, Victorian Infect Dis Serv, Parkville, Vic, Australia

来源：

INTERNAL MEDICINE JOURNAL | 2014年 / 44卷 / 12B期

关键词：

antifungal prophylaxis; Aspergillus; Candida; stem cell transplantation; haematological malignancy; INVASIVE FUNGAL-INFECTIONS; LIPOSOMAL AMPHOTERICIN-B; ACUTE MYELOID-LEUKEMIA; PEDIATRIC-PATIENTS; DOUBLE-BLIND; RISK-FACTORS; FLUCONAZOLE PROPHYLAXIS; NEUTROPENIC PATIENTS; PULMONARY ASPERGILLOSIS; CLINICAL EFFECTIVENESS;

D O I：

10.1111/imj.12595

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is a strong argument for the use of antifungal prophylaxis in high-risk patients given the significant mortality associated with invasive fungal disease, the late identification of these infections, and the availability of safe and well-tolerated prophylactic medications. Clinical decisions about which patients should receive prophylaxis and choice of antifungal agent should be guided by risk stratification, knowledge of local fungal epidemiology, the efficacy and tolerability profile of available agents, and estimates such as number needed to treat and number needed to harm. There have been substantial changes in practice since the 2008 guidelines were published. These include the availability of new medications and/or formulations, and a focus on refining and simplifying patient risk stratification. Used in context, these guidelines aim to assist clinicians in providing optimal preventive care to this vulnerable patient demographic.

引用

页码：1283 / 1297

页数：15

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