Post-translational modifications in signal integration

被引：609
|
作者：
Deribe, Yonathan Lissanu [2 ,3 ]
Pawson, Tony [1 ]
Dikic, Ivan [2 ,3 ]
机构：
[1] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Ctr Syst Biol, Toronto, ON M5G 1X5, Canada
[2] Goethe Univ Frankfurt, Frankfurt Inst Mol Life Sci, Frankfurt, Germany
[3] Goethe Univ Frankfurt, Inst Biochem 2, Frankfurt, Germany
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2010年 / 17卷 / 06期
关键词：
GROWTH-FACTOR RECEPTOR; UBIQUITIN-BINDING DOMAINS; KAPPA-B ACTIVATION; DNA-DAMAGE; PROTEIN-KINASE; LYSINE ACETYLATION; PROLINE HYDROXYLATION; TRANSLESION SYNTHESIS; CONJUGATING ENZYME; TYROSINE KINASES;
D O I：
10.1038/nsmb.1842
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Post-translational modifications of proteins and the domains that recognize these modifications have central roles in creating a highly dynamic relay system that reads and responds to alterations in the cellular microenvironment. Here we review the common principles of post-translational modifications and their importance in signal integration underlying epidermal growth factor receptor signaling and endocytosis, DNA-damage responses and immunity.
引用
收藏
页码：666 / 672
页数：7
相关论文
共 50 条
  • [1] Post-translational modifications in signal integration
    Yonathan Lissanu Deribe
    Tony Pawson
    Ivan Dikic
    Nature Structural & Molecular Biology, 2010, 17 : 666 - 672
  • [2] Emerging roles of post-translational modifications in signal transduction and angiogenesis
    Rahimi, Nader
    Costello, Catherine E.
    PROTEOMICS, 2015, 15 (2-3) : 300 - 309
  • [3] POST-TRANSLATIONAL MODIFICATIONS OF HEMOGLOBIN
    BUNN, HF
    HAEMATOLOGIA, 1984, 17 (02) : 179 - 186
  • [4] The evolution of post-translational modifications
    Bradley, David
    CURRENT OPINION IN GENETICS & DEVELOPMENT, 2022, 76
  • [5] Post-translational modifications in neurodegeneration
    Didonna, Alessandro
    Benetti, Federico
    AIMS BIOPHYSICS, 2016, 3 (01): : 27 - 49
  • [6] Post-translational modifications of proteins
    Carr, SA
    FASEB JOURNAL, 1997, 11 (09): : A1121 - A1121
  • [7] Post-translational modifications of microtubules
    Wloga, Dorota
    Gaertig, Jacek
    JOURNAL OF CELL SCIENCE, 2010, 123 (20) : 3447 - 3455
  • [8] Post-translational modifications of tubulin
    Magiera, Maria M.
    Janke, Carsten
    CURRENT BIOLOGY, 2014, 24 (09) : R351 - R354
  • [9] Exploiting post-translational modifications
    Liszewski, K
    GENETIC ENGINEERING NEWS, 2005, 25 (01): : 22 - 22
  • [10] Post-translational modifications of lantibiotics
    Kupke, T
    Gotz, F
    ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, 1996, 69 (02): : 139 - 150
12345