Bovine major histocompatibility complex (BoLA) heterozygote advantage against the outcome of bovine leukemia virus infection

被引：10
作者：
Lo, Chieh-Wen [1 ,2 ]
Takeshima, Shin-nosuke [3 ,4 ]
Wada, Satoshi [5 ]
Matsumoto, Yasunobu [1 ,2 ]
Aida, Yoko [1 ,2 ,4 ]
机构：
[1] Univ Tokyo, Grad Sch Agr & Life Sci, Lab Global Infect Dis Control Sci, Tokyo, Japan
[2] Univ Tokyo, Grad Sch Agr & Life Sci, Lab Global Anim Resource Sci, Tokyo, Japan
[3] Jumonji Univ, Dept Food & Nutr, Saitama, Japan
[4] RIKEN, Viral Infect Dis Unit, Saitama, Japan
[5] RIKEN Ctr Adv Photon, Photon Control Technol Team, Wako, Saitama, Japan
来源：
HLA | 2021年 / 98卷 / 02期
基金：
日本学术振兴会;
关键词：
association study; BoLA‐ DRB3; bovine leukemia virus; heterozygosity; lymphoma; proviral load; resistance; susceptibility; BLV-COCOMO-QPCR; PROVIRAL LOAD; CLASS-I; ALLELES; CATTLE; HLA; SUSCEPTIBILITY; POLYMORPHISM; ASSOCIATION; RESISTANCE;
D O I：
10.1111/tan.14285
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Bovine leukemia virus (BLV) causes enzootic bovine leucosis. Host genetic heterozygosity at the major histocompatibility complex can enhance the ability to combat infectious diseases. However, heterozygote advantage is loci specific and depends on disease type. Bovine leukocyte antigen (BoLA)-DRB3 polymorphisms are related with BLV-infection outcome; however, whether BoLA-DRB3 heterozygotes have an advantage against BLV-induced lymphoma and proviral load (PVL) remains unclear. By analyzing 1567 BLV-infected individuals, we found that BoLA-DRB3 heterozygous status was significantly associated with lymphoma resistance irrespective of cattle breeds (p < 0.0001). Similarly, decreased PVL was observed in BoLA-DRB3 heterozygotes (p = 0.0407 for Holstein cows; p = 0.0889 for Japanese Black cattle). Our report provides first evidence of BoLA-DRB3 heterozygote advantage against BLV infection outcome.
引用
收藏
页码：132 / 139
页数：8
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