The Effects of Aloe vera on Wound Healing i n Cell Proliferation,Migration, and Viability

被引:1
作者
Teplicki, Eric [1 ]
Ma, Qianli [1 ]
Castillo, David E. [1 ]
Zarei, Mina [1 ]
Hustad, Adam P. [1 ]
Chen, Juan [1 ]
Li, Jie [1 ]
机构
[1] Univ Miami, Miller Sch Med, Dept Dermatol & Cutaneous Surg, 1600 NW 10th Ave,RMSB 2023A, Miami, FL 33136 USA
来源
WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE | 2018年 / 30卷 / 09期
关键词
Aloe vera; wound healing; cell migration; cell proliferation; cell viability; ENDOTHELIAL-CELLS; DERMAL WOUNDS; MIGRATION; GEL;
D O I
暂无
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Introduction. Aloe vera is sometimes used as a folk remedy for minor wounds and burns, but its mechanisms of action in wound healing are unclear. Objective. In this study, the authors evaluate the effects of A vera on wound healing. Materials and Methods. In vitro analyses of cell proliferation and migration were conducted on normal human primary skin fibroblasts and keratinocytes in growth media with A vera solution and preservatives at various concentrations. Growth media with preservatives but without A vera solution served as the control. Results. Aloe vera had significant stimulatory effects on cell proliferation and migration of both fibroblasts and keratinocytes. Surprisingly, A vera also exhibited strong protective effects on preservative-induced keratinocyte death. Keratinocytes in the growth media with both the preservatives and A vera had dramatically higher viability than cells in the control media without A vera. Conclusions. vera accelerates wound healing by promoting the proliferation and migration of fibroblasts and keratinocytes and by protecting keratinocytes from preservative-induced death.
引用
收藏
页码:263 / 268
页数:6
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