Evidence for the Involvement of Lfc and Tctex-1 in Axon Formation

被引：33

作者：

Conde, Cecilia ^{[1
]}

Arias, Cristina ^{[1
]}

Robin, Maria ^{[1
]}

Li, Aiqun ^{[2
]}

Saito, Masaki ^{[2
]}

Chuang, Jen-Zen ^{[2
]}

Nairn, Angus C. ^{[4
]}

Sung, Ching-Hwa ^{[2
,3
]}

Caceres, Alfredo ^{[1
]}

机构：

[1] Consejo Nacl Invest Cient & Tecn, Inst Invest Med Mercedes & Martin Ferreyra, RA-5016 Cordoba, Argentina

[2] Cornell Univ, Weil Med Coll, Dept Ophthalmol, New York, NY 10012 USA

[3] Cornell Univ, Weil Med Coll, Dept Cell & Dev Biol, New York, NY 10012 USA

[4] Yale Univ, Dept Psychiat, New Haven, CT 06511 USA

来源：

JOURNAL OF NEUROSCIENCE | 2010年 / 30卷 / 19期

基金：

美国国家卫生研究院;

关键词：

DYNEIN LIGHT-CHAIN; NEURONAL POLARITY; RHO-GTPASES; CYTOPLASMIC DYNEIN; PAR COMPLEX; KINASE; GROWTH; ESTABLISHMENT; MORPHOGENESIS; RHOA/ROCK;

D O I：

10.1523/JNEUROSCI.5420-09.2010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

RhoA and Rac play key and opposite roles during neuronal polarization. We now show that Lfc, a guanosine nucleotide exchange factor (GEF), localizes to the Golgi apparatus and growth cones of developing neurons and negatively regulates neurite sprouting and axon formation through a Rho signaling pathway. Tctex-1, a dynein light chain implicated in axon outgrowth by modulating actin dynamics and Rac activity, colocalizes and physically interacts with Lfc, thus inhibiting its GEF activity, decreasing Rho-GTP levels, and functionally antagonizing Lfc during neurite formation.

引用

页码：6793 / 6800

页数：8

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