Estrogen-Receptor Expression and Function in Female Reproductive Disease

被引：188

作者：

Tang, Zi-Run ^{[1
]}

Zhang, Rui ^{[1
]}

Lian, Zheng-Xing ^{[1
]}

Deng, Shou-Long ^{[2
]}

Yu, Kun ^{[1
]}

机构：

[1] China Agr Univ, Beijing Key Lab Anim Genet Improvement, Natl Engn Lab Anim Breeding, Key Lab Anim Genet & Breeding,Minist Agr,Coll Ani, Beijing 100193, Peoples R China

[2] Chinese Acad Sci, CAS Key Lab Genome Sci & Informat, Beijing Inst Genom, Beijing 100101, Peoples R China

来源：

CELLS | 2019年 / 8卷 / 10期

关键词：

estrogen receptor; ovary; female reproductive disease; POLYCYSTIC-OVARY-SYNDROME; PROTEIN-COUPLED RECEPTOR; GROWTH-FACTOR RECEPTOR; BREAST-CANCER; ER-BETA; NUCLEAR RECEPTORS; GENE-EXPRESSION; MEDIATED TRANSCRIPTION; MENSTRUAL-CYCLE; ALPHA;

D O I：

10.3390/cells8101123

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Estrogen receptors (ER) include ER alpha, ER beta and new membrane receptor G protein-coupled receptor 30 (GPR30). Estrogen receptors are key receptors to maintain ovarian granulosa cell differentiation, follicle and oocyte growth and development, and ovulation function. The abnormal functions of estrogen, its receptors, and estradiol synthesis-related enzymes are closely related to clinical reproductive endocrine diseases, such as polycystic ovary syndrome (PCOS) and endometriosis (EMS). At present, hormone therapy is the main treatment for ovarian-related diseases, and a stable hormone environment is established by regulating ovarian function. In recent years, some estrogen-related drugs have made great progress, such as clomiphene, which is a nonsteroidal antiestrogen drug in clinical application. This article elaborates on the regulatory role of estrogen and its nuclear receptors and membrane receptors in oocyte development, especially female reproductive diseases related to the abnormal expression of estrogen and its receptors. We also highlighted the latest advances of treatment strategy for these diseases and the application of related targeted small molecule drugs in clinical research and treatment, so as to provide reference for the treatment of female reproductive diseases.

引用

页数：15

共 102 条

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