Characterisation of isolated α-synuclein filaments from substantia nigra of Parkinson's disease brain

被引：131
作者：
Crowther, RA
Daniel, SE
Goedert, M
机构：
[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
[2] UCL, Inst Neurol, Parkinsons Dis Soc Brain Res Ctr, London WC1N 1PJ, England
来源：
NEUROSCIENCE LETTERS | 2000年 / 292卷 / 02期
基金：
英国医学研究理事会;
关键词：
alpha-synuclein; Lewy bodies; Lewy neurites; isolated filaments; substantia nigra; Parkinson's disease; dementia with Lewy bodies; multiple system atrophy;
D O I：
10.1016/S0304-3940(00)01440-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The defining neuropathological deposits of Parkinson's disease, dementia with Lewy bodies and multiple system atrophy are strongly immunoreactive for alpha-synuclein. We have shown previously that isolated filaments from dementia with Lewy bodies and multiple system atrophy brains are labelled in a characteristic fashion by a number of alpha-synuclein antibodies. Here we have extracted filaments from substantia nigra of patients with idiopathic Parkinson's disease. Antibodies directed against the carboxy-terminal region of alpha-synuclein labelled isolated filaments along their entire lengths. By contrast, an antibody directed against the amino-terminal region of alpha-synuclein only labelled one filament end. These characteristics were identical to those of fi laments extracted from brains of patients with dementia with Lewy bodies and multiple system atrophy. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
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页码：128 / 130
页数：3
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