Characteristics of Lipo-Oligosaccharide Loci of Campylobacter jejuni Isolates Associated with Guillain-Barre Syndrome from Hebei, China

被引：4

作者：

Jiang, Hai ^{[1
]}

Zhang, Mao-Jun ^{[1
]}

Liu, Rui-Chun ^{[2
]}

Tian, Xin-Ying ^{[2
]}

Gu, Yi-Xin ^{[1
]}

Zhang, Jian-Zhong ^{[1
]}

机构：

[1] Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, Beijing 102206, Peoples R China

[2] Hebei Med Univ, Hosp 2, Dept Neurol, Shijiazhuang 050051, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2010年 / 11卷 / 03期

关键词：

Campylobacter jejuni; Guillain-Barre syndrome; lipo-oligosaccharides; MILLER-FISHER-SYNDROME; CORE OLIGOSACCHARIDE; GANGLIOSIDE MIMICRY; LIPOPOLYSACCHARIDES; BIOSYNTHESIS; RABBITS; ANTIBODIES; INDUCTION; ENTERITIS; STRAINS;

D O I：

10.3390/ijms11031155

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ganglioside mimicry by C. jejuni lipo-oligosaccharides (LOS) could induce the production of autoantibodies against gangliosides and the development of Guillain-Barre syndrome (GBS). The LOS biosynthesis region exhibits significant variation with different strains. Using PCR amplifications of genes from published LOS loci and sequencing the LOS biosynthesis loci, the eight GBS-associated C. jejuni strains from HeBei could be classified into four classes. The expression of sialylated LOS structures (class A) or non-sialylated LOS structures(class F, H and P) in the C. jejuni LOS is considered to be two different factors for the induction of GBS.

引用

页码：1155 / 1161

页数：7

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