The chemokine system in cancer biology and therapy

被引：301
作者：
Mantovani, Alberto [1 ,2 ]
Savino, Benedetta [1 ,2 ]
Locati, Massimo [1 ,2 ]
Zammataro, Luca [1 ]
Allavena, Paola [1 ]
Bonecchi, Raffaella [1 ,2 ]
机构：
[1] Ist Clin Humanitas, IRCCS, I-20089 Rozzano, Milan, Italy
[2] Univ Milan, Dept Translat Med, I-20089 Milan, Italy
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2010年 / 21卷 / 01期
关键词：
Chemokine; Cancer; Chemokine Receptor; Inflammation; LYMPH-NODE METASTASIS; HUMAN BREAST-CANCER; REGULATORY T-CELLS; NATURAL-KILLER-CELLS; MONOCYTE CHEMOATTRACTANT PROTEIN-1; HUMAN PANCREATIC-CANCER; DUFFY-ANTIGEN RECEPTOR; TUMOR-ASSOCIATED MACROPHAGES; MESENCHYMAL STEM-CELLS; GROWTH IN-VIVO;
D O I：
10.1016/j.cytogfr.2009.11.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chemokines are a key component of cancer-related inflammation. Chemokines and chemokine receptors are downstream of genetic events that cause neoplastic transformation and are components of chronic inflammatory conditions, which predispose to cancer. Components of the chemokine system affect in a cell autonomous or non-autonomous way multiple pathways of tumor progression, including: leukocyte recruitment and function; cellular senescence; tumor cell proliferation and survival; invasion and metastasis. Available information in preclinical and clinical settings suggests that the chemokine system represents a valuable target for the development of innovative therapeutic strategies. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：27 / 39
页数：13
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