Circadian control of tissue homeostasis and adult stem cells

被引：35

作者：

Janich, Peggy ^{[1
]}

Meng, Qing-Jun ^{[2
]}

Benitah, Salvador Aznar ^{[3
,4
]}

机构：

[1] Univ Lausanne, Ctr Integrat Genom, CH-1015 Lausanne, Switzerland

[2] Univ Manchester, Fac Life Sci, Manchester M13 9PL, Lancs, England

[3] Catalan Inst Res & Adv Studies ICREA, Barcelona, Spain

[4] Inst Res Biomed IRB Barcelona, Barcelona, Spain

来源：

CURRENT OPINION IN CELL BIOLOGY | 2014年 / 31卷

基金：

英国医学研究理事会;

关键词：

REV-ERB-ALPHA; CLOCK GENE-EXPRESSION; ARNT-LIKE; METABOLISM; MICE; MODULATION; BEHAVIOR; BMAL1; BRAIN; PROLIFERATION;

D O I：

10.1016/j.ceb.2014.06.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The circadian timekeeping mechanism adapts physiology to the 24-hour light/dark cycle. However, how the outputs of the circadian clock in different peripheral tissues communicate and synchronize each other is still not fully understood. The circadian clock has been implicated in the regulation of numerous processes, including metabolism, the cell cycle, cell differentiation, immune responses, redox homeostasis, and tissue repair. Accordingly, perturbation of the machinery that generates circadian rhythms is associated with metabolic disorders, premature ageing, and various diseases including cancer. Importantly, it is now possible to target circadian rhythms through systemic or local delivery of time cues or compounds. Here, we summarize recent findings in peripheral tissues that link the circadian clock machinery to tissue-specific functions and diseases.

引用

页码：8 / 15

页数：8

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