Thermal Isomerization of Cannabinoid Analogues

被引：26

作者：

Garcia, Angie ^{[1
]}

Borchardt, Dan ^{[1
]}

Chang, Chia-En A. ^{[1
]}

Marsella, Michael J. ^{[1
]}

机构：

[1] Univ Calif Riverside, Dept Chem, Riverside, CA 92521 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 46期

关键词：

RECEPTOR;

D O I：

10.1021/ja907062v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Thermal isomerization of CBCan to THCan [nonaromatic analogues of plant cannabinoids cannabichromene (CBC) and Delta(1)-tetrahydrocannabinol (THC), respectively] is predicted in silico and demonstrated experimentally. Density functional theory calculations support a similar isomerization mechanism for the corresponding plant cannabinoids. Docking studies suggest that THCan, although nonaromatic, has a CB1 receptor binding affinity similar to that of natural

引用

页码：16640 / +

页数：4

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