Metformin decreases glycated albumin to glycated haemoglobin ratio in patients with newly diagnosed type 2 diabetes

被引：6

作者：

Sumitani, Satoru ^{[1
,2
]}

Morita, Shinya ^{[2
]}

Deguchi, Reiko ^{[2
]}

Hirai, Koichi ^{[2
]}

Mukai, Kosuke ^{[2
]}

Utsu, Yoshihiko ^{[2
]}

Miki, Shunji ^{[2
]}

Sato, Bunzo ^{[2
]}

Nakamura, Hideji ^{[1
]}

Kasayama, Soji ^{[2
]}

Koga, Masafumi ^{[3
]}

机构：

[1] Nissay Hosp, Ctr Prevent Med, Osaka 5500012, Japan

[2] Nissay Hosp, Dept Med, Osaka 5500012, Japan

[3] Kawanishi City Hosp, Dept Internal Med, Kawanishi, Japan

来源：

ANNALS OF CLINICAL BIOCHEMISTRY | 2015年 / 52卷 / 01期

关键词：

Glycated haemoglobin; glycated albumin; metformin; type; 2; diabetes; postprandial hyperglycaemia; GLUCOSE EXCURSION; INSULIN; MELLITUS; IMPACT; HBA1C;

D O I：

10.1177/0004563214522984

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background To know whether metformin improves postprandial hyperglycaemia, we examined the effect of metformin on the glycated albumin (GA) to glycated haemoglobin (HbA(1c)) ratio (GA/HbA(1c) ratio) in patients with newly diagnosed type 2 diabetes. Methods Metformin and lifestyle interventions were initiated in 18 patients with newly diagnosed type 2 diabetes. Metformin was titrated to 1500mg/day or maximum-tolerated dose. HbA(1c) and GA were measured every four weeks up to 24 weeks. Results HbA(1c) decreased significantly from 9.02.1% at baseline to 6.5 +/- 0.9% at week 24, and GA decreased significantly from 24.3 +/- 8.2% to 16.2 +/- 3.1%. The GA/HbA(1c) ratio decreased significantly from 2.66 +/- 0.37 at baseline to 2.47 +/- 0.29 at week 24 (P<0.01), despite that the GA/HbA(1c) ratio reached a plateau value at week 16. The change in the GA/HbA(1c) ratio during 24 weeks (GA/HbA(1c) ratio) was significantly correlated with both baseline HbA(1c) and GA. Moreover, the GA/HbA(1c) ratio was significantly correlated with the change in GA during 24 weeks but not with the change in HbA(1c). Conclusions Metformin decreased the GA/HbA(1c) ratio in patients with newly diagnosed type 2 diabetes. This suggests that metformin improves postprandial hyperglycaemia in patients with newly diagnosed type 2 diabetes.

引用

页码：76 / 81

页数：6

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