PdI2-Catalyzed Regioselective Cyclocarbonylation of 2-Allyl Phenols to Dihydrocoumarins

被引：36

作者：

Amezquita-Valencia, Manuel ^{[1
]}

Alper, Howard ^{[1
]}

机构：

[1] Univ Ottawa, Dept Chem, Ctr Catalysis Res & Innovat, Ottawa, ON K1N 6N5, Canada

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 22期

基金：

加拿大自然科学与工程研究理事会;

关键词：

7-MEMBERED RING LACTONES; ONE-POT SYNTHESIS; ASYMMETRIC-SYNTHESIS; SELECTIVE SYNTHESIS; CATALYZED SYNTHESIS; PALLADIUM; LACTAMS; 3,4-DIHYDROCOUMARINS; DECARBOXYLATION; CARBONYLATION;

D O I：

10.1021/ol5029157

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, efficient, and regioselective synthesis of 3-methyl-3,4-dihydrocoumarins is reported. The reaction of 2-allyl phenols with synthesis gas was catalyzed by PdI2, and 1,3,5,7-tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane (L1) and 1,3,5,7-tetramethyl-6-tetradecyl-2,4,8-trioxa-6-phosphaadamantane (L2) were effective as ligands, affording good product selectivity in all cases.

引用

页码：5827 / 5829

页数：3

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