Neurotransmitter Mechanisms of Morphine Withdrawal Syndrome

被引：10

作者：

Lelevich, S. V. ^{[1
]}

Lelevich, V. V. ^{[1
]}

Novokshonov, A. A. ^{[1
]}

机构：

[1] Grodno State Med Univ, Grodno, BELARUS

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2009年 / 148卷 / 02期

关键词：

morphine; brain; dopamine; norepinephrine; gamma-aminobutyric acid;

D O I：

10.1007/s10517-009-0672-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Activity of the major neurotransmitter systems in the brainstem and cerebellum was studied in rats with morphine withdrawal syndrome. The most significant changes were found in the brainstem of animals by the 36th hour and 7 days after morphine withdrawal. Dysfunction was revealed in the dopaminergic, noradrenergic, and serotoninergic neurotransmitter systems. Changes in cerebellar neurotransmission were most pronounced by the end of the first week of morphine withdrawal syndrome and manifested in the prevalence of inhibitory processes.

引用

页码：184 / 187

页数：4