Reversed phase chromatography of some homologous ferrocenoyl amides

Under this research, a reversed phase high performance liquid chromatography (RP-HPLC) separation condition has been found for two series of homologous ferrocenoyl amides: Fc(CH2)(m) CONH(CH2)(n)H (m=1-3, n=4-8) and by reversed phase thin layer chromatography (RP-TLC). The effect of separation for the above two homologous series is satisfactory in the RP-TLC and the RP-HPLC. When "m" was the same and "n" was different, a linear relationship was found between the values of R-M, log K' of the homologs and "n", and between the log K' and the fraction of the organic modifier in the mobile phase (R-M = log (1/R-f - 1) and Fe = C5H5FeC5H4. When "m" was different but "n" was same, all the first members (m=0) of each group of homologs deviated from a linear relationship between the values of R-M, logK' and "m" of the solute.