Design, Synthesis, Characterization, Swelling and in Vitro Drug Release Behavior of Composite Hydrogel Beads Based on Methotrexate and Chitosan Incorporating Antipyrine Moiety

被引：17

作者：

Bary, E. M. Abdel ^{[1
]}

Harmal, Ammar N. ^{[1
,2
]}

Saeed, Ali ^{[1
,2
]}

Gouda, Moustafa A. ^{[3
]}

机构：

[1] Mansoura Univ, Dept Chem, Fac Sci, Mansoura, Egypt

[2] Saadah Univ, Dept Chem, Fac Sci, Saadah, Yemen

[3] Taibah Univ, Dept Chem, Fac Sci & Arts, Ulla, Saudi Arabia

来源：

POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING | 2018年 / 57卷 / 18期

关键词：

Chitosan; hydrogel; in vitro drug release; methotrexate; PHARMACEUTICAL APPLICATIONS; MEMBRANES; CELLULOSE; PVA;

D O I：

10.1080/03602559.2018.1447126

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Novel biodegradable pH and thermal-responsive hydrogels were prepared for controlled drug delivery studies via reaction of chitosan with 4-chloroacetylantipyrine in DMF/H2O, followed by heating of the formed poly [acetylantipyrine-chitosan] with glutaraldehyde as a crosslinking agent to give the hydrogels. These hydrogels were subjected to equilibrium swelling studies at different temperatures (25 degrees C, 37 degrees C and 45 degrees C) in solutions of pH 2.1 and 7.4. Methotrexate (MTX) was entrapped in the hydrogels, and drug release studies were carried out at 37 degrees C in solutions at pH 2.1 and 7.4. [GRAPHICS]

引用

页码：1906 / 1914

页数：9

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